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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Nolan Ryan* | 5714 | 1966-1993 | |
| 2 | Randy Johnson* | 4875 | 1988-2009 | |
| 3 | Roger Clemens | 4672 | 1984-2007 | |
| 4 | Steve Carlton* | 4136 | 1965-1988 | |
| 5 | Clayton Kershaw* | 3881 | 2008-2027 | |
| 6 | Chris Christenson# | 3717 | 2033-2047 | |
| 7 | Bert Blyleven* | 3701 | 1970-1992 | |
| 8 | Tom Seaver* | 3640 | 1967-1986 | |
| 9 | Don Sutton* | 3574 | 1966-1988 | |
| 10 | Chris Sale* | 3546 | 2010-2029 | |
| 11 | Gaylord Perry* | 3534 | 1962-1983 | |
| 12 | Walter Johnson* | 3509 | 1907-1927 | |
| 13 | Noah Syndergaard* | 3396 | 2015-2032 | |
| 14 | Greg Maddux* | 3371 | 1986-2008 | |
| 15 | Phil Niekro* | 3342 | 1964-1987 | |
| 16 | Maddox Pelley | 3299 | 2024-2039 | |
| 17 | Jody Myers | 3277 | 2027-2043 | |
| 18 | Jon Purves# | 3246 | 2031-2047 | |
| 19 | Fergie Jenkins* | 3192 | 1965-1983 | |
| 20 | Pedro Martinez* | 3154 | 1992-2009 | |
| 21 | Bob Gibson* | 3117 | 1959-1975 | |
| 22 | Curt Schilling | 3116 | 1988-2007 | |
| 23 | John Smoltz* | 3084 | 1988-2009 | |
| 24 | Brad Louis | 3042 | 2033-2046 | |
| 25 | Doug Ancrum* | 2958 | 2026-2041 | |
| 26 | Justin Verlander* | 2945 | 2005-2021 | |
| 27 | Cole Hamels | 2915 | 2006-2023 | |
| 28 | Felix Hernandez* | 2878 | 2005-2021 | |
| 29 | Jim Bunning* | 2855 | 1955-1971 | |
| 30 | Blake Snell* | 2839 | 2016-2033 | |
| 31 | Mickey Lolich | 2832 | 1963-1979 | |
| 32 | CC Sabathia* | 2828 | 2001-2017 | |
| 33 | Mike Mussina | 2813 | 1991-2008 | |
| 34 | Cy Young* | 2803 | 1890-1911 | |
| 35 | Frank Tanana | 2773 | 1973-1993 | |
| 36 | Luis Mendoza | 2740 | 2030-2043 | |
| 37 | Ignacio Reyna# | 2722 | 2032-2047 | |
| 38 | Sergio Uribe | 2714 | 2030-2045 | |
| 39 | Madison Bumgarner* | 2701 | 2009-2026 | |
| 40 | Julio Urias* | 2681 | 2016-2032 | |
| 41 | David Cone | 2668 | 1986-2003 | |
| 42 | Danny Salazar | 2629 | 2013-2031 | |
| 43 | Max Scherzer | 2619 | 2008-2021 | |
| 44 | Chuck Finley | 2610 | 1986-2002 | |
| 45 | Juan Osorio# | 2609 | 2036-2047 | |
| 46 | Tom Glavine* | 2607 | 1987-2008 | |
| 47 | Warren Spahn* | 2583 | 1942-1965 | |
| 48 | Debebe Naguib# | 2582 | 2034-2047 | |
| 49 | Bob Feller* | 2581 | 1936-1956 | |
| 50 | Joel Gilles# | 2580 | 2034-2047 | |
| 51 | Tim Keefe* | 2562 | 1880-1893 | |
| 52 | Jacob deGrom | 2561 | 2014-2030 | |
| 53 | Joe Meyers# | 2558 | 2033-2047 | |
| 54 | Jerry Koosman | 2556 | 1967-1985 | |
| 55 | Javier Vazquez | 2536 | 1998-2011 | |
| 56 | Corey Kluber* | 2533 | 2011-2027 | |
| 57 | Carlos Rodon | 2524 | 2015-2032 | |
| 58 | Jorge Morales | 2514 | 2031-2046 | |
| 59 | A.J. Burnett | 2513 | 1999-2015 | |
| 60 | Christy Mathewson* | 2502 | 1900-1916 | |
| 61 | Carlos Martinez | 2491 | 2013-2028 | |
| 62 | Don Drysdale* | 2486 | 1956-1969 | |
| 63 | Rick Porcello | 2483 | 2009-2029 | |
| 64 | Jack Morris | 2478 | 1977-1994 | |
| 65 | Mark Langston | 2464 | 1984-1999 | |
| 66 | Jim Kaat | 2461 | 1959-1983 | |
| 67 | Sam McDowell | 2453 | 1961-1975 | |
| 68 | Andy Pettitte | 2448 | 1995-2013 | |
| 69 | Jamie Moyer | 2441 | 1986-2012 | |
| 70 | Chris Ostertag# | 2421 | 2033-2047 | |
| 71 | Luis Tiant | 2416 | 1964-1982 | |
| 72 | Jose Quintana | 2411 | 2012-2027 | |
| 73 | Dennis Eckersley* | 2401 | 1975-1998 | |
| 74 | Kevin Brown | 2397 | 1986-2005 | |
| 75 | Sandy Koufax* | 2396 | 1955-1966 | |
| 76 | Josh Gazda# | 2391 | 2033-2047 | |
| 77 | Bartolo Colon | 2385 | 1997-2017 | |
| 78 | Zack Greinke | 2370 | 2004-2022 | |
| 79 | Rodolfo Flores# | 2362 | 2034-2047 | |
| 79 | Charlie Hough | 2362 | 1970-1994 | |
| 81 | Robin Roberts* | 2357 | 1948-1966 | |
| 82 | David Price | 2355 | 2008-2021 | |
| 83 | Lupe Aguilar | 2340 | 2028-2043 | |
| 84 | Early Wynn* | 2334 | 1939-1963 | |
| 85 | Scott Schreiber | 2314 | 2021-2035 | |
| 86 | Juan Marichal* | 2303 | 1960-1975 | |
| 87 | Doug Boakye# | 2299 | 2035-2045 | |
| 88 | Dwight Gooden | 2293 | 1984-2000 | |
| 89 | Rube Waddell* | 2267 | 1900-1910 | |
| 90 | Lefty Grove* | 2266 | 1925-1941 | |
| 91 | John Lackey | 2252 | 2002-2017 | |
| 92 | Tommy John | 2245 | 1963-1989 | |
| 93 | Arturo Romero | 2235 | 2031-2045 | |
| 94 | Joel Vitarelli | 2233 | 2026-2038 | |
| 95 | Jon Lester | 2231 | 2006-2019 | |
| 96 | J.B. Bukauskas | 2221 | 2020-2033 | |
| 97 | Luis de Alba | 2216 | 2022-2037 | |
| 98 | Jim Palmer* | 2212 | 1965-1984 | |
| 99 | Jake Peavy | 2207 | 2002-2016 | |
| 100 | David Wells | 2201 | 1987-2007 |
