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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Esteban Espinoza# | 13.29 | 2033-2047 | |
| 2 | Craig Kimbrel* | 13.02 | 2010-2026 | |
| 3 | Maddox Pelley | 12.48 | 2024-2039 | |
| 4 | Conor Billings | 12.24 | 2029-2043 | |
| 5 | Chris Christenson# | 11.98 | 2033-2047 | |
| 6 | Ken Giles | 11.84 | 2014-2031 | |
| 7 | Jeff Putnam# | 11.75 | 2036-2047 | |
| 8 | Kenley Jansen* | 11.63 | 2010-2029 | |
| 9 | Austin Brice | 11.60 | 2016-2028 | |
| 10 | Doug Boakye# | 11.53 | 2035-2045 | |
| 11 | Luis Mendoza | 11.51 | 2030-2043 | |
| 12 | Jonathan Martin | 11.49 | 2023-2039 | |
| 13 | Eric Doggett | 11.40 | 2027-2034 | |
| 14 | Juan Osorio# | 11.12 | 2036-2047 | |
| 15 | Robun Uchida | 11.00 | 2020-2037 | |
| 16 | David Robertson | 10.91 | 2008-2024 | |
| 17 | Rob Hopkins | 10.88 | 2030-2045 | |
| 18 | Chris Robbins# | 10.87 | 2037-2047 | |
| 19 | Jim Kopczynski | 10.67 | 2036-2043 | |
| 20 | Sergio Mendoza | 10.64 | 2022-2041 | |
| 21 | Randy Johnson* | 10.61 | 1988-2009 | |
| 22 | Joe Meyers# | 10.59 | 2033-2047 | |
| 22 | Arturo Castillo | 10.59 | 2027-2041 | |
| 24 | Jonathan Define# | 10.45 | 2035-2047 | |
| 25 | Brad Louis | 10.37 | 2033-2046 | |
| 26 | Doug Montgomery | 10.34 | 2029-2040 | |
| 27 | Francisco Rodriguez | 10.33 | 2002-2017 | |
| 27 | Jorge Esquivel | 10.33 | 2030-2044 | |
| 29 | Kerry Wood | 10.32 | 1998-2012 | |
| 30 | Michael Kopech | 10.27 | 2019-2032 | |
| 31 | Dwain McFadyen | 10.24 | 2030-2043 | |
| 31 | Debebe Naguib# | 10.24 | 2034-2047 | |
| 33 | Jared Hicks | 10.23 | 2029-2037 | |
| 34 | Jorge Morales | 10.22 | 2031-2046 | |
| 35 | Luis Samarripa | 10.21 | 2032-2039 | |
| 36 | Juan Miranda | 10.17 | 2024-2038 | |
| 37 | Juan Ramirez | 10.15 | 2024-2038 | |
| 38 | Sergio Uribe | 10.14 | 2030-2045 | |
| 39 | Patrick Naughton | 10.11 | 2022-2029 | |
| 40 | Alfredo Pesina | 10.08 | 2029-2036 | |
| 41 | Pedro Martinez* | 10.04 | 1992-2009 | |
| 42 | Walt Lewis | 9.99 | 2032-2044 | |
| 43 | Juan Ayala# | 9.89 | 2035-2047 | |
| 43 | Scott Schreiber | 9.89 | 2021-2035 | |
| 45 | Kevin Egler# | 9.86 | 2037-2047 | |
| 46 | Yu Darvish | 9.82 | 2012-2022 | |
| 47 | Luis Magdaleno | 9.80 | 2028-2040 | |
| 48 | Juan Anaya | 9.77 | 2028-2038 | |
| 49 | Juan Ventura | 9.76 | 2029-2041 | |
| 50 | Juan Ramirez# | 9.74 | 2035-2047 | |
| 51 | Erik Ford# | 9.73 | 2040-2047 | |
| 51 | Mike Wood# | 9.73 | 2039-2047 | |
| 53 | Jeff Bryson# | 9.65 | 2042-2047 | |
| 54 | Mike Norris | 9.59 | 2026-2038 | |
| 55 | Jorge Angon | 9.56 | 2026-2037 | |
| 56 | Jon Koban# | 9.55 | 2039-2047 | |
| 56 | Nolan Ryan* | 9.55 | 1966-1993 | |
| 58 | Luis Madariaga# | 9.54 | 2039-2047 | |
| 59 | Dave McDermott | 9.48 | 2030-2044 | |
| 60 | Gregorio Caban | 9.47 | 2033-2040 | |
| 61 | Joel Gilles# | 9.46 | 2034-2047 | |
| 62 | Luis Rubalcaba | 9.44 | 2029-2038 | |
| 62 | Jody Myers | 9.44 | 2027-2043 | |
| 64 | Max Scherzer | 9.43 | 2008-2021 | |
| 64 | Sergio Reynoso | 9.43 | 2027-2037 | |
| 66 | Oliver Perez | 9.40 | 2002-2019 | |
| 66 | Stephen Strasburg | 9.40 | 2010-2026 | |
| 68 | Jeff Fisher | 9.38 | 2028-2041 | |
| 69 | Trevor Hoffman* | 9.36 | 1993-2010 | |
| 70 | Chris Ostertag# | 9.32 | 2033-2047 | |
| 71 | Juan Harnandez | 9.31 | 2031-2044 | |
| 72 | Sergio Belez | 9.29 | 2026-2040 | |
| 72 | Tim Lincecum | 9.29 | 2007-2016 | |
| 74 | Sandy Koufax* | 9.28 | 1955-1966 | |
| 75 | Jose Berrios | 9.26 | 2016-2028 | |
| 76 | Michael Lorenzen | 9.24 | 2015-2029 | |
| 77 | Wade Davis | 9.22 | 2009-2023 | |
| 77 | Dusty Cassanova | 9.22 | 2030-2040 | |
| 79 | Brad Zambelli | 9.21 | 2026-2037 | |
| 80 | Ignacio Reyna# | 9.20 | 2032-2047 | |
| 81 | Talbot Winman# | 9.16 | 2040-2047 | |
| 82 | Sergio Vargas | 9.15 | 2027-2034 | |
| 83 | Clayton Kershaw* | 9.07 | 2008-2027 | |
| 83 | Mike Cantrell | 9.07 | 2032-2040 | |
| 85 | Joaquin Benoit | 9.04 | 2001-2017 | |
| 85 | Danny Salazar | 9.04 | 2013-2031 | |
| 87 | Robbie Ray | 9.03 | 2014-2027 | |
| 87 | Francisco Liriano | 9.03 | 2005-2019 | |
| 87 | Jorge Escobar# | 9.03 | 2038-2047 | |
| 90 | Greg Dallas | 9.01 | 2033-2041 | |
| 91 | Zach Britton* | 8.98 | 2011-2029 | |
| 92 | Arturo Romero | 8.97 | 2031-2045 | |
| 93 | Chris Sale* | 8.92 | 2010-2029 | |
| 94 | Jamie Colangelo# | 8.91 | 2032-2047 | |
| 94 | Juan Rojas | 8.91 | 2030-2044 | |
| 96 | Tim Gagne# | 8.90 | 2036-2047 | |
| 97 | Juan Barrientos | 8.89 | 2023-2033 | |
| 97 | Jasiah McCoo | 8.89 | 2032-2044 | |
| 99 | Max Blockmon# | 8.88 | 2031-2046 | |
| 100 | Jeurys Familia | 8.87 | 2012-2027 |
