| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Ben Gibbons | CWS | KC | June 30, 2106 | 20-6 | 6 | 4 | 9 | 2 | 4 | 0 | 125 |
| 2 | Joseph Thomson | BAL | NYY | Sept. 2, 2106 | 15-4 | 5 | 4 | 7 | 3 | 4 | 0 | 120 |
| 3 | Jose Jaramillo | STL | CHC | Aug. 21, 2106 | 21-3 | 5 | 4 | 5 | 2 | 5 | 1 | 113 |
| 4 | Pat Warner | CIN | NYM | Sept. 30, 2106 | 16-2 | 4 | 4 | 6 | 1 | 4 | 1 | 112 |
| 5 | Jacob Sessions | LV | DET | May 25, 2106 | 12-11 | 7 | 4 | 7 | 3 | 3 | 1 | 110 |
| 6 | Gerardo Machado | CIN | WAS | May 23, 2106 | 11-5 | 5 | 5 | 3 | 2 | 5 | 0 | 106 |
| 7 | Brandon Thomas | KC | CWS | June 29, 2106 | 10-7 | 5 | 5 | 5 | 2 | 3 | 0 | 106 |
| 8 | Eric Fairweather | ATL | LAD | May 30, 2106 | 11-5 | 4 | 4 | 5 | 2 | 4 | 0 | 105 |
| 9 | Leo Lepe | CWS | DET | Sept. 14, 2106 | 16-6 | 5 | 4 | 6 | 1 | 4 | 0 | 103 |
| 10 | Bill Lindberg | ATL | NYM | July 10, 2106 | 10-2 | 5 | 5 | 5 | 1 | 3 | 0 | 101 |
| 11 | Brian Ellis | TOR | SF | July 9, 2106 | 14-3 | 5 | 3 | 7 | 3 | 3 | 0 | 101 |
| 12 | Marcos Iniguez | TOR | TB | Aug. 26, 2106 | 15-3 | 4 | 3 | 8 | 2 | 2 | 0 | 100 |
| 13 | Jeremy Kenealy | SD | LAD | Sept. 21, 2106 | 11-1 | 3 | 3 | 5 | 3 | 3 | 1 | 100 |
| 14 | David Elson | COL | WAS | June 14, 2106 | 17-4 | 5 | 4 | 4 | 2 | 4 | 1 | 99 |
| 15 | Alex Flores | MIL | ARI | Sept. 16, 2106 | 9-8 | 5 | 3 | 6 | 3 | 3 | 1 | 99 |
| 16 | Chris Boley | MIL | WAS | April 21, 2106 | 10-4 | 4 | 4 | 5 | 1 | 3 | 1 | 98 |
| 17 | Chad Crane | CIN | WAS | Sept. 10, 2106 | 8-2 | 4 | 3 | 6 | 3 | 3 | 0 | 98 |
| 18 | Ryan Builes | CWS | OAK | April 15, 2106 | 11-5 | 6 | 5 | 3 | 1 | 5 | 0 | 97 |
| 19 | Chris Becerra | WAS | NYM | Sept. 18, 2106 | 9-8 | 4 | 4 | 4 | 1 | 3 | 2 | 96 |
| 20 | Ben Gibbons | CWS | LAA | July 24, 2106 | 8-6 | 3 | 3 | 6 | 1 | 2 | 2 | 95 |
| 21 | Eduardo Roman | LAD | SF | June 19, 2106 | 8-4 | 3 | 3 | 5 | 3 | 3 | 0 | 95 |
| 22 | Mel Garcia | MIL | NYY | Aug. 3, 2106 | 13-4 | 5 | 3 | 7 | 2 | 2 | 1 | 94 |
| 23 | Joe Hardie | ATL | CIN | May 24, 2106 | 10-7 | 5 | 3 | 6 | 3 | 3 | 0 | 94 |
| 24 | Matt Beck | OAK | TEX | May 5, 2106 | 8-2 | 5 | 4 | 4 | 2 | 4 | 0 | 94 |
| 25 | Matt Beck | OAK | SEA | Sept. 12, 2106 | 8-2 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 26 | Allan Alessi | LAA | SEA | Sept. 1, 2106 | 15-0 | 5 | 5 | 4 | 1 | 3 | 0 | 94 |
| 27 | Danny Ellis | BOS | BAL | May 1, 2106 | 9-6 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 28 | Jamie Sullivan | OAK | SEA | Aug. 17, 2106 | 13-6 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 29 | Jacob Sessions | LV | DET | May 24, 2106 | 10-13 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 30 | Roy Fontaine | ATL | PHI | July 2, 2106 | 18-7 | 4 | 3 | 6 | 2 | 3 | 0 | 93 |