| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Robby Bethel | ARI | CIN | Sept. 24, 2110 | 13-6 | 6 | 5 | 8 | 3 | 3 | 0 | 128 |
| 2 | Kyle Phillips | SF | HOU | June 16, 2110 | 21-0 | 5 | 5 | 6 | 2 | 3 | 2 | 123 |
| 3 | Jon Hall | COL | CLE | May 24, 2110 | 17-13 | 4 | 4 | 6 | 1 | 4 | 1 | 112 |
| 4 | Joey Owens | NYY | MIN | April 15, 2110 | 9-6 | 5 | 4 | 6 | 2 | 3 | 0 | 101 |
| 5 | Eric Hemphill | SEA | PHI | July 25, 2110 | 8-4 | 5 | 4 | 6 | 2 | 3 | 0 | 101 |
| 6 | Sam Jaynes | WAS | PIT | April 11, 2110 | 8-10 | 4 | 4 | 4 | 3 | 3 | 1 | 101 |
| 7 | Robby Bethel | ARI | CHC | Aug. 15, 2110 | 7-8 | 5 | 4 | 5 | 3 | 3 | 0 | 99 |
| 8 | Travis Dawley | BOS | LV | May 7, 2110 | 12-5 | 4 | 3 | 5 | 2 | 4 | 1 | 98 |
| 9 | Bobby Noriega | LAD | HOU | June 4, 2110 | 10-1 | 4 | 3 | 6 | 2 | 3 | 1 | 98 |
| 10 | Vic Rivera | TOR | NYY | June 4, 2110 | 11-6 | 4 | 3 | 6 | 2 | 3 | 1 | 98 |
| 11 | Cameron Goudy | BOS | LAA | June 19, 2110 | 11-7 | 4 | 3 | 6 | 2 | 3 | 1 | 98 |
| 12 | Chad Gutshall | STL | CIN | June 3, 2110 | 4-5 | 4 | 4 | 4 | 3 | 3 | 0 | 96 |
| 13 | Justin Dunsmore | OAK | MIN | April 18, 2110 | 11-2 | 5 | 3 | 7 | 2 | 3 | 0 | 96 |
| 14 | Devin Maurer | CWS | DET | Sept. 1, 2110 | 13-2 | 4 | 3 | 4 | 3 | 4 | 1 | 96 |
| 15 | Scott Griffith | KC | SF | June 14, 2110 | 9-4 | 4 | 3 | 9 | 1 | 1 | 0 | 95 |
| 16 | Kyle Eby | MIN | OAK | Nov. 4, 2110 | 11-2 | 5 | 4 | 5 | 2 | 3 | 0 | 94 |
| 17 | Leo Lepe | CWS | TB | Aug. 29, 2110 | 10-4 | 5 | 4 | 5 | 2 | 3 | 0 | 94 |
| 18 | Dennis Schickel | MIL | COL | June 29, 2110 | 11-1 | 4 | 4 | 5 | 1 | 3 | 0 | 93 |
| 19 | Brian Schoenberg | COL | STL | June 9, 2110 | 13-10 | 3 | 3 | 4 | 2 | 3 | 2 | 93 |
| 20 | Dan Wimmer | TB | NYM | Oct. 1, 2110 | 19-2 | 6 | 4 | 6 | 1 | 3 | 0 | 92 |
| 21 | Oscar Cabanas | SD | SF | July 29, 2110 | 9-2 | 4 | 3 | 5 | 3 | 3 | 0 | 91 |
| 22 | Casey Peterson | DET | NYY | May 2, 2110 | 12-5 | 4 | 3 | 6 | 2 | 2 | 1 | 91 |
| 23 | Willie Serrano | NYY | COL | July 13, 2110 | 10-11 | 4 | 3 | 5 | 3 | 3 | 0 | 91 |
| 24 | Hans Cabedo | COL | DET | May 28, 2110 | 9-2 | 4 | 3 | 5 | 3 | 3 | 0 | 91 |
| 25 | Jeff Pettinato | DET | SF | June 27, 2110 | 9-4 | 4 | 3 | 4 | 2 | 4 | 1 | 91 |
| 26 | Kyle Phillips | LAD | SEA | July 30, 2110 | 7-5 | 4 | 4 | 5 | 2 | 2 | 0 | 91 |
| 27 | Chris Gosdin | PHI | CLE | Sept. 23, 2110 | 13-0 | 4 | 3 | 4 | 2 | 4 | 1 | 91 |
| 28 | Jeremy Kenealy | SD | DET | Aug. 16, 2110 | 11-6 | 5 | 2 | 7 | 2 | 3 | 1 | 89 |
| 29 | Vic Rivera | TOR | BAL | July 28, 2110 | 10-3 | 5 | 4 | 6 | 1 | 2 | 0 | 89 |
| 30 | Alex Baeza | KC | TB | Oct. 3, 2110 | 10-2 | 5 | 4 | 5 | 1 | 3 | 0 | 89 |