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| Thursday, April 5th, 2018 |
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| Traded 32-year-old starting pitcher David Price to the St. Louis Cardinals, getting 23-year-old minor league closer Ryan Helsley and 29-year-old starting pitcher Miles Mikolas in return. |
| Placed SP Miles Mikolas on the active roster. |
| Optioned RP Austin Maddox to Double A Portland. |
| Saturday, March 31st, 2018 |
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| Assigned RP Fernando Rodriguez to Triple A Pawtucket. |
| Thursday, March 22nd, 2018 |
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| Traded 23-year-old minor league reliever Mike Shawaryn and 18-year-old minor league right fielder Tyler Esplin to the Chicago White Sox, getting 32-year-old reliever Nate Jones in return. |
| Optioned SP William Cuevas to Triple A Pawtucket. |
| Placed RP Nate Jones on the active roster. |
| RP Fernando Rodriguez was designated for assignment and placed on waivers. |
| Optioned RP Bobby Poyner to Triple A Pawtucket. |
| Placed RP Tony Zych on the 60-day disabled list. |
| Placed 1B Miguel Cabrera on the active roster. |
| Placed SP Drew Pomeranz on the active roster. |
| Activated SP Drew Pomeranz from the disabled list. |
| Placed SP Eduardo Rodriguez on the active roster. |
| Activated SP Eduardo Rodriguez from the disabled list. |
| Thursday, March 15th, 2018 |
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| Traded 34-year-old first baseman Hanley Ramirez, 18-year-old minor league starting pitcher Bryan Mata and 19-year-old minor league right fielder Cole Brannen to the Detroit Tigers, getting 34-year-old first baseman Miguel Cabrera, retaining 50% in return. |
| Placed RP Tony Zych on the active roster. |
| Tuesday, March 13th, 2018 |
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| Signed free agent RP Tony Zych to a 1-year contract worth a total of $1,200,000. |
| Fired scouting director Mike Rikard. |
| Signed scouting director Norio Yamaguchi to a 5-year, $2,070,000 per year contract. |
| Monday, March 12th, 2018 |
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| Signed RP Joe Kelly to a 2-year contract extension worth a total of $8,400,000. |
