| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jordan Lyles | CIN | SF | March 29, 2025 | 7-0 | 8.2 | 0 | 3 | 0 | 1 | 10 | 94 |
| 2 | Jason Dumont | DET | CHW | April 6, 2025 | 6-0 | 8.1 | 0 | 2 | 0 | 1 | 6 | 90 |
| 3 | Yoshinobu Yamamoto | TEX | LAD | April 19, 2025 | 3-0 | 9.0 | 0 | 0 | 0 | 5 | 6 | 90 |
| 4 | Grayson Rodriguez | CLE | SD | April 2, 2025 | 0-1 | 8.2 | 1 | 4 | 0 | 1 | 10 | 89 |
| 5 | Mark Davies | PIT | CIN | April 13, 2025 | 2-0 | 8.0 | 0 | 3 | 0 | 1 | 8 | 88 |
| 6 | Collin Hurrell | SF | CIN | March 27, 2025 | 3-0 | 8.0 | 0 | 5 | 0 | 0 | 10 | 88 |
| 7 | Roki Sasaki | CLE | KC | March 29, 2025 | 2-0 | 7.0 | 0 | 2 | 0 | 1 | 11 | 87 |
| 8 | Tyson Oswalt | TBR | LAA | April 10, 2025 | 4-1 | 7.1 | 0 | 3 | 0 | 1 | 10 | 86 |
| 9 | José Padilla | SEA | TEX | April 11, 2025 | 1-0 | 8.0 | 0 | 5 | 0 | 0 | 8 | 86 |
| 10 | Shane McClanahan | SD | COL | April 13, 2025 | 3-0 | 7.0 | 0 | 2 | 0 | 1 | 9 | 85 |
| 11 | Alex Holtmann | LAA | TEX | April 16, 2025 | 5-2 | 7.1 | 1 | 2 | 0 | 2 | 10 | 83 |
| 12 | Alex Early | BAL | BOS | April 2, 2025 | 5-3 | 8.2 | 1 | 6 | 0 | 0 | 6 | 83 |
| 13 | Sean Gilmartin | TOR | ATL | April 14, 2025 | 4-7 | 7.2 | 2 | 1 | 0 | 2 | 8 | 82 |
| 14 | Pedro Magana | PHI | COL | April 2, 2025 | 1-0 | 6.2 | 0 | 2 | 0 | 0 | 6 | 82 |
| 15 | Paul Erickson | LAA | CHW | March 27, 2025 | 9-1 | 7.1 | 1 | 2 | 0 | 2 | 9 | 82 |
| 16 | Alex Watts | KC | MIN | April 9, 2025 | 5-0 | 7.0 | 0 | 3 | 0 | 1 | 7 | 81 |
| 17 | Brent Frazier | PIT | CIN | April 12, 2025 | 2-0 | 7.0 | 0 | 2 | 0 | 1 | 5 | 81 |
| 18 | Jordan Lyles | CIN | MIL | April 5, 2025 | 6-2 | 9.0 | 2 | 2 | 1 | 1 | 5 | 81 |
| 19 | Mark Appel | TOR | BOS | April 8, 2025 | 6-1 | 7.0 | 0 | 4 | 0 | 1 | 9 | 81 |
| 20 | Shohei Ohtani | ARI | MIA | April 17, 2025 | 7-1 | 7.0 | 1 | 3 | 0 | 0 | 8 | 81 |
| 21 | Bill Black | HOU | NYM | March 30, 2025 | 7-5 | 6.2 | 0 | 1 | 0 | 3 | 9 | 81 |
| 22 | Jeff Reynolds | CIN | MIL | April 3, 2025 | 4-0 | 8.1 | 0 | 3 | 0 | 4 | 5 | 81 |
| 23 | Bill Black | HOU | MIN | April 5, 2025 | 3-5 | 6.1 | 0 | 2 | 0 | 1 | 9 | 81 |
| 24 | Hunter Johnson | SAC | SD | April 8, 2025 | 6-0 | 7.1 | 0 | 1 | 0 | 4 | 6 | 80 |
| 25 | Stephen Strasburg | NYY | ARI | April 3, 2025 | 1-3 | 6.2 | 0 | 3 | 0 | 0 | 6 | 80 |
| 26 | Kevin Nicholas | STL | NYM | April 20, 2025 | 2-0 | 7.0 | 0 | 4 | 0 | 1 | 7 | 79 |
| 27 | Craig Cooper | MIN | STL | March 29, 2025 | 6-0 | 7.0 | 0 | 3 | 0 | 1 | 5 | 79 |
| 28 | Rod Swift | ATL | PHI | April 8, 2025 | 8-1 | 7.0 | 1 | 4 | 0 | 1 | 10 | 79 |
| 29 | Forrest Whitley | NYM | MIA | April 7, 2025 | 0-4 | 6.0 | 0 | 1 | 0 | 1 | 7 | 79 |
| 30 | Brusdar Graterol | COL | LAD | April 15, 2025 | 3-4 | 6.0 | 0 | 2 | 0 | 0 | 6 | 78 |