| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Justin Hooper | SEA | SF | April 3, 2021 | 11-0 | 9.0 | 0 | 0 | 0 | 2 | 16 | 106 |
| 2 | Alberto Vega | NYM | STL | May 6, 2021 | 7-0 | 8.1 | 0 | 3 | 0 | 0 | 15 | 99 |
| 3 | Alberto Vega | NYM | CHC | April 20, 2021 | 5-0 | 9.0 | 0 | 3 | 0 | 0 | 10 | 98 |
| 4 | Hunter Johnson | TBR | KC | April 20, 2021 | 4-0 | 9.0 | 0 | 5 | 0 | 0 | 12 | 96 |
| 5 | Juan Dávila | HOU | NYY | May 4, 2021 | 6-0 | 8.1 | 0 | 3 | 0 | 0 | 10 | 94 |
| 6 | Juan García | DET | OAK | April 16, 2021 | 16-0 | 9.0 | 0 | 3 | 0 | 0 | 5 | 93 |
| 7 | Danny Hultzen | SEA | HOU | April 29, 2021 | 8-0 | 8.1 | 0 | 3 | 0 | 0 | 8 | 92 |
| 8 | Steven Matz | LAA | TBR | May 3, 2021 | 7-0 | 8.0 | 0 | 2 | 0 | 1 | 9 | 91 |
| 9 | Albert Suarez | SF | SD | April 5, 2021 | 6-0 | 8.2 | 0 | 2 | 0 | 1 | 4 | 90 |
| 10 | Shane McClanahan | SD | PIT | April 14, 2021 | 3-0 | 8.0 | 0 | 2 | 0 | 1 | 8 | 90 |
| 11 | Zach Potter | STL | CIN | April 25, 2021 | 4-1 | 8.1 | 1 | 3 | 0 | 0 | 8 | 89 |
| 12 | Gary Griffith | PIT | CIN | May 12, 2021 | 3-1 | 7.1 | 0 | 4 | 0 | 1 | 15 | 89 |
| 13 | Dylan Bundy | NYY | BAL | April 7, 2021 | 3-0 | 8.0 | 0 | 3 | 0 | 1 | 9 | 89 |
| 14 | José Fierro | CHW | DET | April 29, 2021 | 5-1 | 8.0 | 0 | 4 | 0 | 0 | 9 | 89 |
| 15 | Ronald Dunham | COL | SF | April 9, 2021 | 1-2 | 8.0 | 1 | 1 | 0 | 2 | 8 | 87 |
| 16 | Brady Singer | LAA | TBR | May 5, 2021 | 3-0 | 8.0 | 0 | 4 | 0 | 0 | 7 | 87 |
| 17 | Kolby Allard | ATL | CHC | April 28, 2021 | 2-1 | 7.0 | 0 | 4 | 0 | 0 | 13 | 87 |
| 18 | Jon Simpson | WAS | ATL | May 4, 2021 | 6-0 | 8.1 | 0 | 3 | 0 | 1 | 5 | 87 |
| 19 | Dave Smith | STL | COL | May 7, 2021 | 2-0 | 8.0 | 0 | 2 | 0 | 2 | 6 | 86 |
| 20 | Dave Groves | BOS | TEX | May 2, 2021 | 4-1 | 7.1 | 1 | 1 | 0 | 1 | 9 | 86 |
| 21 | Gerrit Cole | BOS | NYM | April 27, 2021 | 7-0 | 7.2 | 0 | 2 | 0 | 2 | 7 | 85 |
| 22 | Brent Frazier | LAD | SD | April 22, 2021 | 2-1 | 8.0 | 1 | 2 | 1 | 0 | 10 | 85 |
| 23 | Sean Gilmartin | PHI | ATL | May 8, 2021 | 2-1 | 8.0 | 1 | 4 | 0 | 0 | 8 | 85 |
| 24 | Nathan Kirby | MIN | CHW | May 11, 2021 | 6-0 | 8.1 | 0 | 5 | 0 | 0 | 5 | 85 |
| 25 | Danny Hultzen | SEA | CHW | April 7, 2021 | 4-0 | 8.0 | 0 | 6 | 0 | 1 | 10 | 84 |
| 26 | Todd Howard | OAK | TBR | May 8, 2021 | 2-0 | 8.0 | 0 | 4 | 0 | 1 | 6 | 84 |
| 27 | Will Rainey | HOU | DET | April 13, 2021 | 10-0 | 7.2 | 0 | 3 | 0 | 1 | 6 | 84 |
| 28 | Casey Mize | KC | DET | May 11, 2021 | 9-0 | 7.1 | 0 | 1 | 0 | 1 | 4 | 84 |
| 29 | Kevin Gausman | LAA | HOU | May 12, 2021 | 1-0 | 8.0 | 0 | 4 | 0 | 0 | 4 | 84 |
| 30 | Lucas Giolito | OAK | TBR | April 29, 2021 | 1-2 | 8.0 | 2 | 3 | 0 | 0 | 7 | 83 |