| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Alberto Vega | NYM | MIL | July 6, 2021 | 5-0 | 9.0 | 0 | 2 | 0 | 0 | 16 | 106 |
| 2 | Justin Hooper | SEA | SF | April 3, 2021 | 11-0 | 9.0 | 0 | 0 | 0 | 2 | 16 | 106 |
| 3 | Archie Bradley | SEA | TEX | May 30, 2021 | 7-0 | 9.0 | 0 | 0 | 0 | 2 | 13 | 103 |
| 4 | Shelby Miller | OAK | TEX | June 21, 2021 | 4-0 | 9.0 | 0 | 2 | 0 | 1 | 11 | 99 |
| 5 | Alberto Vega | NYM | STL | May 6, 2021 | 7-0 | 8.1 | 0 | 3 | 0 | 0 | 15 | 99 |
| 6 | Jon Lester | TOR | TBR | July 9, 2021 | 2-0 | 9.0 | 0 | 1 | 0 | 0 | 7 | 99 |
| 7 | Danny Hultzen | SEA | COL | June 23, 2021 | 6-0 | 9.0 | 0 | 1 | 0 | 0 | 6 | 98 |
| 8 | Alberto Vega | NYM | CHC | April 20, 2021 | 5-0 | 9.0 | 0 | 3 | 0 | 0 | 10 | 98 |
| 9 | Hunter Johnson | TBR | KC | April 20, 2021 | 4-0 | 9.0 | 0 | 5 | 0 | 0 | 12 | 96 |
| 10 | Mark Appel | SEA | OAK | July 25, 2021 | 3-1 | 8.2 | 1 | 2 | 0 | 0 | 11 | 96 |
| 11 | Matthew Liberatore | DET | CLE | May 24, 2021 | 1-0 | 8.0 | 0 | 2 | 0 | 1 | 13 | 95 |
| 12 | Juan Alvarado | SD | CHC | June 7, 2021 | 6-0 | 9.0 | 0 | 2 | 0 | 1 | 7 | 95 |
| 13 | Danny Hultzen | SEA | OAK | July 24, 2021 | 3-2 | 8.0 | 0 | 2 | 0 | 2 | 14 | 94 |
| 14 | Juan Dávila | HOU | NYY | May 4, 2021 | 6-0 | 8.1 | 0 | 3 | 0 | 0 | 10 | 94 |
| 15 | Kyle Funkhouser | LAA | OAK | June 14, 2021 | 1-0 | 8.0 | 0 | 1 | 0 | 0 | 8 | 94 |
| 16 | Juan García | DET | OAK | April 16, 2021 | 16-0 | 9.0 | 0 | 3 | 0 | 0 | 5 | 93 |
| 17 | Alex Watts | MIA | NYM | May 21, 2021 | 4-0 | 9.0 | 0 | 4 | 0 | 0 | 7 | 93 |
| 18 | Melvin Garner | PIT | NYM | July 9, 2021 | 3-0 | 7.2 | 0 | 1 | 0 | 0 | 9 | 93 |
| 19 | Kris Bubic | KC | DET | May 21, 2021 | 4-0 | 9.0 | 0 | 3 | 0 | 0 | 5 | 93 |
| 20 | Sean Gilmartin | PHI | MIA | May 20, 2021 | 2-1 | 9.0 | 1 | 4 | 0 | 0 | 10 | 93 |
| 21 | Danny Hultzen | SEA | HOU | April 29, 2021 | 8-0 | 8.1 | 0 | 3 | 0 | 0 | 8 | 92 |
| 22 | Andrew Morales | ARI | LAD | July 11, 2021 | 5-0 | 8.0 | 0 | 1 | 0 | 2 | 10 | 92 |
| 23 | Pedro Cuevas | MIL | PIT | June 13, 2021 | 5-3 | 7.0 | 0 | 2 | 0 | 0 | 14 | 92 |
| 24 | Josh Tomlin | CLE | CHW | July 30, 2021 | 5-0 | 9.0 | 0 | 3 | 0 | 1 | 6 | 92 |
| 25 | John Bauer | MIN | DET | July 27, 2021 | 4-0 | 8.0 | 0 | 2 | 0 | 1 | 10 | 92 |
| 26 | Kevin Comer | STL | CHC | July 11, 2021 | 1-0 | 8.0 | 0 | 2 | 0 | 1 | 10 | 92 |
| 27 | Steven Matz | LAA | TBR | May 3, 2021 | 7-0 | 8.0 | 0 | 2 | 0 | 1 | 9 | 91 |
| 28 | Mark Davies | WAS | TBR | June 30, 2021 | 1-0 | 8.0 | 0 | 3 | 0 | 0 | 9 | 91 |
| 29 | Craig Cooper | STL | CLE | July 27, 2021 | 6-0 | 9.0 | 0 | 4 | 0 | 0 | 5 | 91 |
| 30 | Albert Suarez | SF | SD | April 5, 2021 | 6-0 | 8.2 | 0 | 2 | 0 | 1 | 4 | 90 |