| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Hunter Johnson | TBR | CHW | June 4, 2022 | 3-0 | 9.0 | 0 | 1 | 0 | 0 | 10 | 102 |
| 2 | Todd Howard | OAK | TEX | April 23, 2022 | 2-0 | 9.0 | 0 | 0 | 0 | 0 | 6 | 100 |
| 3 | John Larson | OAK | PHI | April 9, 2022 | 3-0 | 9.0 | 0 | 0 | 0 | 0 | 5 | 99 |
| 4 | Kyle Funkhouser | LAA | HOU | April 20, 2022 | 2-0 | 9.0 | 0 | 4 | 0 | 0 | 11 | 97 |
| 5 | Jordan Lyles | CIN | ARI | June 15, 2022 | 2-0 | 9.0 | 0 | 3 | 0 | 1 | 10 | 96 |
| 6 | Kevin Comer | STL | TBR | June 8, 2022 | 2-0 | 9.0 | 0 | 3 | 0 | 0 | 8 | 96 |
| 7 | Lucas Giolito | MIN | BAL | July 1, 2022 | 1-0 | 8.1 | 0 | 0 | 0 | 3 | 11 | 95 |
| 8 | Daulton Jefferies | SD | MIA | May 6, 2022 | 0-2 | 8.1 | 0 | 2 | 0 | 0 | 8 | 94 |
| 9 | Tim Lincecum | TOR | TEX | April 8, 2022 | 9-0 | 9.0 | 0 | 2 | 0 | 2 | 7 | 93 |
| 10 | Clayton Kershaw | COL | SF | May 10, 2022 | 7-0 | 8.2 | 0 | 2 | 0 | 1 | 7 | 93 |
| 11 | Richard White | MIA | SF | June 3, 2022 | 2-0 | 9.0 | 0 | 4 | 0 | 0 | 7 | 93 |
| 12 | Craig Cooper | STL | SF | May 8, 2022 | 6-0 | 9.0 | 0 | 5 | 0 | 1 | 10 | 92 |
| 13 | John Bauer | MIN | CHW | April 22, 2022 | 2-0 | 8.0 | 0 | 2 | 0 | 1 | 10 | 92 |
| 14 | Paul Erickson | LAA | BOS | June 6, 2022 | 1-0 | 7.2 | 0 | 2 | 0 | 0 | 9 | 91 |
| 15 | Paul Erickson | LAA | CHW | June 27, 2022 | 8-0 | 7.1 | 0 | 1 | 0 | 0 | 9 | 91 |
| 16 | Brady Singer | LAA | NYY | June 2, 2022 | 4-0 | 7.1 | 0 | 2 | 0 | 0 | 11 | 91 |
| 17 | Mark Appel | SEA | OAK | June 30, 2022 | 11-0 | 8.2 | 0 | 2 | 0 | 4 | 11 | 91 |
| 18 | Jordan Lyles | CIN | CHC | June 30, 2022 | 5-0 | 9.0 | 0 | 6 | 0 | 1 | 10 | 90 |
| 19 | Albert Suarez | DET | KC | July 1, 2022 | 4-1 | 8.1 | 0 | 3 | 0 | 1 | 8 | 90 |
| 20 | Miguel Pineda | COL | SF | May 16, 2022 | 6-1 | 8.2 | 1 | 4 | 0 | 0 | 9 | 90 |
| 21 | Brady Singer | LAA | TEX | April 16, 2022 | 5-2 | 8.0 | 0 | 3 | 0 | 0 | 8 | 90 |
| 22 | Daulton Jefferies | SD | CIN | April 18, 2022 | 0-2 | 8.1 | 0 | 4 | 0 | 0 | 8 | 90 |
| 23 | Jorge Fernández | MIA | SD | May 6, 2022 | 2-0 | 9.0 | 0 | 5 | 0 | 0 | 6 | 90 |
| 24 | Jon Simpson | WAS | HOU | May 14, 2022 | 3-1 | 8.0 | 0 | 2 | 0 | 1 | 8 | 90 |
| 25 | Emílio Salazar | ARI | MIA | May 4, 2022 | 1-3 | 8.0 | 0 | 2 | 0 | 1 | 8 | 90 |
| 26 | Todd Collins | TEX | KC | May 10, 2022 | 8-0 | 8.0 | 0 | 2 | 0 | 1 | 7 | 89 |
| 27 | Pedro Magana | PHI | OAK | April 8, 2022 | 4-1 | 8.0 | 1 | 2 | 0 | 1 | 10 | 89 |
| 28 | Mark Appel | SEA | LAA | June 25, 2022 | 8-0 | 7.2 | 0 | 3 | 0 | 1 | 11 | 89 |
| 29 | Kyle Funkhouser | LAA | PHI | June 5, 2022 | 6-2 | 8.0 | 0 | 4 | 0 | 0 | 9 | 89 |
| 30 | Danny Hultzen | SEA | BAL | May 31, 2022 | 14-1 | 9.0 | 1 | 6 | 0 | 1 | 11 | 88 |