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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| Alex O'Connell | 2021-2024 | .259 | 73 | 239 | 0 | 0 | 0 | 0.00 | 0 |
| Justin O'Conner | 2017-2021 | .210 | 14 | 48 | 0 | 0 | 0 | 0.00 | 0 |
| Aaron O'Day | 2023-2023 | .000 | 0 | 0 | 2 | 0 | 0 | 3.50 | 38 |
| Darren O'Day | 2012-2017 | .000 | 0 | 0 | 8 | 3 | 8 | 4.32 | 154 |
| Henry O'Day | 2018-2022 | .240 | 13 | 81 | 0 | 0 | 0 | 0.00 | 0 |
| John O'Day | 2016-2024 | .191 | 1 | 5 | 34 | 32 | 132 | 3.70 | 498 |
| Donald O'Dell | 2023-2023 | .206 | 1 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| Eric O'Flaherty | 2012-2020 | .077 | 0 | 0 | 31 | 27 | 20 | 3.89 | 501 |
| Trent O'Hannon | 2018-2024 | .255 | 11 | 64 | 0 | 0 | 0 | 0.00 | 0 |
| John O'Herlihy | 2021-2024 | .254 | 0 | 13 | 0 | 0 | 0 | 0.00 | 0 |
| Dustin O'Neal | 2017-2021 | .240 | 19 | 98 | 0 | 0 | 0 | 0.00 | 0 |
| Clayton O'Neil | 2022-2024 | .000 | 0 | 0 | 1 | 4 | 2 | 4.61 | 35 |
| John O'Quinn | 2012-2020 | .500 | 0 | 0 | 35 | 35 | 130 | 2.74 | 522 |
| Sean O'Sullivan | 2013-2014 | .000 | 0 | 0 | 7 | 15 | 0 | 4.62 | 123 |
| Brett Oberholtzer | 2012-2020 | .089 | 0 | 0 | 24 | 18 | 8 | 3.84 | 379 |
| Ted Obregon | 2013-2013 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Leonardo Ochoa | 2014-2019 | .264 | 52 | 231 | 0 | 0 | 0 | 0.00 | 0 |
| Jake Odorizzi | 2012-2021 | .123 | 0 | 8 | 41 | 70 | 3 | 4.67 | 754 |
| Alexi Ogando | 2012-2017 | .150 | 0 | 1 | 15 | 14 | 4 | 4.31 | 260 |
| Tadanobu Ogawa | 2015-2015 | .154 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Mike Ogden | 2019-2024 | .235 | 60 | 173 | 0 | 0 | 0 | 0.00 | 0 |
| Masutaro Ohayashi | 2014-2024 | .277 | 300 | 998 | 0 | 0 | 0 | 0.00 | 0 |
| Sotan Ohayashi | 2014-2015 | .229 | 3 | 31 | 0 | 0 | 0 | 0.00 | 0 |
| Michael Ohlman | 2015-2019 | .236 | 6 | 41 | 0 | 0 | 0 | 0.00 | 0 |
| Shohei Ohtani | 2019-2024 | .260 | 73 | 232 | 55 | 26 | 0 | 3.35 | 749 |
| Pedro Okuda | 2017-2021 | .233 | 10 | 79 | 0 | 0 | 0 | 0.00 | 0 |
| Jefferson Olacio | 2020-2020 | .000 | 0 | 0 | 0 | 1 | 0 | 9.00 | 9 |
| Andrew Oliver | 2012-2019 | .140 | 0 | 5 | 37 | 47 | 1 | 4.74 | 547 |
| Lester Oliveros | 2012-2021 | .000 | 0 | 0 | 19 | 24 | 18 | 3.91 | 399 |
| Whit Olmstead | 2020-2024 | .225 | 26 | 128 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Michael Olmsted | 2013-2020 | .182 | 1 | 2 | 16 | 17 | 11 | 4.99 | 386 |
| Shane Opitz | 2015-2023 | .256 | 45 | 240 | 0 | 0 | 0 | 0.00 | 0 |
| Juan Oramas | 2017-2023 | .133 | 0 | 1 | 51 | 46 | 8 | 4.28 | 680 |
| Cody Orgeron | 2022-2023 | .191 | 2 | 9 | 0 | 0 | 0 | 0.00 | 0 |
| Paulo Orlando | 2014-2017 | .250 | 3 | 13 | 0 | 0 | 0 | 0.00 | 0 |
| Jesús Orozco | 2022-2024 | .266 | 10 | 41 | 0 | 0 | 0 | 0.00 | 0 |
| Paul Orr | 2022-2024 | .000 | 0 | 0 | 4 | 5 | 0 | 4.32 | 85 |
| Jose Ortega | 2013-2021 | .000 | 0 | 0 | 6 | 9 | 4 | 4.57 | 137 |
| José Ortega | 2022-2022 | .180 | 1 | 9 | 0 | 0 | 0 | 0.00 | 0 |
| Rafael Ortega | 2013-2019 | .268 | 22 | 150 | 0 | 0 | 0 | 0.00 | 0 |
| Daniel Ortiz | 2012-2012 | .333 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Joseph Ortiz | 2014-2016 | .000 | 0 | 0 | 1 | 2 | 0 | 4.35 | 23 |
| Esteban Ortíz | 2012-2020 | .266 | 45 | 261 | 0 | 0 | 0 | 0.00 | 0 |
| Ramón Ortíz | 2019-2022 | .234 | 68 | 161 | 0 | 0 | 0 | 0.00 | 0 |
| Victor Ortíz | 2021-2024 | .000 | 0 | 0 | 2 | 0 | 1 | 2.06 | 34 |
| Bubba Osborn | 2021-2023 | .219 | 14 | 59 | 0 | 0 | 0 | 0.00 | 0 |
| Hiroya Oshima | 2021-2021 | .135 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Josh Osich | 2016-2018 | .000 | 0 | 0 | 14 | 5 | 1 | 4.01 | 120 |
| Roberto Osuna | 2018-2024 | .154 | 0 | 1 | 27 | 15 | 102 | 2.30 | 533 |
| Tyson Oswalt | 2021-2024 | .125 | 0 | 1 | 27 | 26 | 16 | 3.49 | 393 |
| Andy Otero | 2015-2024 | .175 | 0 | 3 | 43 | 45 | 99 | 3.26 | 730 |
| Tadaaki Otsuka | 2015-2018 | .188 | 0 | 0 | 18 | 27 | 0 | 5.08 | 273 |
| Teo Ottenhof | 2019-2024 | .000 | 0 | 0 | 15 | 9 | 11 | 4.30 | 392 |
| Josh Outman | 2013-2013 | .000 | 0 | 0 | 0 | 0 | 0 | 6.75 | 10 |
| Juan Carlos Oviedo | 2012-2015 | .000 | 0 | 0 | 11 | 11 | 6 | 4.01 | 154 |
| Bryan Owen | 2023-2023 | .190 | 0 | 2 | 0 | 0 | 0 | 0.00 | 0 |
| Matt Owen | 2022-2023 | .225 | 5 | 18 | 0 | 0 | 0 | 0.00 | 0 |
| Chris Owings | 2014-2022 | .260 | 52 | 278 | 0 | 0 | 0 | 0.00 | 0 |
| Micah Owings | 2012-2014 | .241 | 0 | 2 | 11 | 18 | 3 | 3.84 | 221 |
| Jun'ichi Ozaki | 2014-2018 | .333 | 0 | 0 | 3 | 1 | 1 | 3.81 | 50 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Marcell Ozuna | 2013-2016 | .195 | 7 | 33 | 0 | 0 | 0 | 0.00 | 0 |
