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| Thursday, July 15th, 2021 |
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| Rochester Red Wings: LF Christian Yelich was designated for assignment. |
| Sunday, June 6th, 2021 |
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| Toledo Mud Hens: Activated RP Ross Bowers from the injured list. |
| Toledo Mud Hens: Activated RP Ross Bowers from the IL. |
| Saturday, May 1st, 2021 |
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| Lehigh Valley IronPigs: Placed SP Brent Powell on the 7-day injured list, retroactive to 04/29/2021. |
| Tuesday, April 20th, 2021 |
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| Scranton WB RailRiders: Signed hitting coach Ruben Rivera. |
| Tuesday, March 9th, 2021 |
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| Gwinnett Stripers: Signed manager Mike Sarbaugh. |
| Monday, February 15th, 2021 |
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| Toledo Mud Hens: Signed pitching coach Adam Bleday. |
| Thursday, December 24th, 2020 |
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| Rochester Red Wings: Signed hitting coach Satoshi Ine. |
| Friday, December 18th, 2020 |
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| Rochester Red Wings: Signed pitching coach Edward Mujica. |
| Tuesday, December 8th, 2020 |
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| Norfolk Tides: Signed hitting coach Julius Matos. |
| Wednesday, November 25th, 2020 |
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| Buffalo Bisons: Signed manager Billy Hatcher. |
| Tuesday, November 17th, 2020 |
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| Norfolk Tides: Signed manager Aaron Boone. |
| Saturday, November 14th, 2020 |
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| Columbus Clippers: Signed manager Bobby Crosby. |
| Thursday, November 12th, 2020 |
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| Pawtucket Red Sox: Signed manager Jose Oquendo. |
| Pawtucket Red Sox: RF John Drennen becomes a free-agent. |
| Pawtucket Red Sox: RF Yasuhiko Takeda becomes a free-agent. |
| Pawtucket Red Sox: LF Michael Reed becomes a free-agent. |
| Buffalo Bisons: 2B Joshua Magee becomes a free-agent. |
| Buffalo Bisons: SS Dan Price becomes a free-agent. |
| Charlotte Knights: 3B Rosell Herrera becomes a free-agent. |
| Columbus Clippers: RP Jorge Serrano becomes a free-agent. |
| Gwinnett Stripers: SP Héctor Cantú becomes a free-agent. |
| Gwinnett Stripers: LF Leonardo Ochoa becomes a free-agent. |
| Gwinnett Stripers: SS Hak-Ju Lee becomes a free-agent. |
| Lehigh Valley IronPigs: RP Heath Hembree becomes a free-agent. |
| Syracuse Chiefs: RP Michael Fiers becomes a free-agent. |
| Syracuse Chiefs: 2B Darwin Barney becomes a free-agent. |
| Tuesday, November 10th, 2020 |
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| Norfolk Tides: Signed pitching coach Jorge Cordova. |
| Sunday, November 8th, 2020 |
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| Columbus Clippers: Signed pitching coach Jake Peavy. |
| Friday, November 6th, 2020 |
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| Lehigh Valley Iron Pigs: Signed manager Juan Bustabad. |
| Tuesday, November 3rd, 2020 |
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| Gwinnett Braves: Activated SP Chris Jackson from the injured list. |
| Gwinnett Braves: Activated SP Chris Jackson from the IL. |
| Gwinnett Braves: Activated RP Don Day from the injured list. |
| Gwinnett Braves: Activated RP Don Day from the IL. |
| Charlotte Knights: Activated SP Scott Alexander from the injured list. |
| Charlotte Knights: Activated SP Scott Alexander from the IL. |
| Scranton WB RailRiders: Activated RP Steve William from the injured list. |
| Scranton WB RailRiders: Activated RP Steve William from the IL. |
| Lehigh Valley Iron Pigs: Activated SP Cal Brunsberg from the injured list. |
| Lehigh Valley Iron Pigs: Activated SP Cal Brunsberg from the IL. |
| Monday, October 26th, 2020 |
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| Columbus Clippers: SP Jered Weaver retires. |
| Columbus Clippers: SS Troy Tulowitzki retires. |
| Durham Bulls: RP Brandon Gomes retires. |
| Columbus Clippers: SP Derek Holland retires. |
| Columbus Clippers: 3B Mohamed Kariuki retires. |
| Indianapolis Indians: C Tom Washington retires. |
| Rochester Red Wings: LF Emory Blumentha retires. |
| Gwinnett Braves: RP David Buck retires. |
| Gwinnett Braves: 3B Tyrone Hogan retires. |
| Durham Bulls: RF Josuke Koyama retires. |
| Durham Bulls: 3B Luis Pérez retires. |
| Rochester Red Wings: C Jun'ichi Suzuki retires. |
| Gwinnett Braves: RP You-liang Liu retires. |
| Louisville Bats: 1B Francisco Coleman retires. |
| Durham Bulls: RF Cory Vaughn retires. |
| Durham Bulls: LF Austin Wates retires. |
| Durham Bulls: RP Ben Hawkins retires. |
| Toledo Mud Hens: CF Diego Herrera retires. |
| Indianapolis Indians: 2B Jorge Aguilar retires. |
| Buffalo Bisons: LF Dave Lowry retires. |
| Norfolk Tides: Manager Reggie Willits leaves the team, his contract was not renewed. |
| Norfolk Tides: Pitching Coach Willie Humphrey leaves the team, his contract was not renewed. |
| Norfolk Tides: Hitting Coach Chris Errecart leaves the team, his contract was not renewed. |
| Pawtucket Red Sox: Manager Tom Nieto leaves the team, his contract was not renewed. |
| Durham Bulls: Manager Juan Bustabad leaves the team, his contract was not renewed. |
| Buffalo Bisons: Manager Gabe Kapler leaves the team, his contract was not renewed. |
| Columbus Clippers: Pitching Coach Jason Hammel leaves the team, his contract was not renewed. |
| Rochester Red Wings: Pitching Coach Bill Bray leaves the team, his contract was not renewed. |
| Rochester Red Wings: Hitting Coach Ruben Rivera leaves the team, his contract was not renewed. |
| Gwinnett Braves: Manager Bobby Magallanes leaves the team, his contract was not renewed. |
| Gwinnett Braves: Hitting Coach Leo Gomez leaves the team, his contract was not renewed. |
| Lehigh Valley Iron Pigs: Manager Jeff Banister leaves the team, his contract was not renewed. |
| Sunday, September 27th, 2020 |
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| Lehigh Valley Iron Pigs: 2B Jonathan Roof was designated for assignment. |
