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| Wednesday, June 29th , 2022 |
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| Indianapolis Indians: Fired Hitting Coach Francisco Morales. |
| Thursday, June 23rd , 2022 |
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| Lehigh Valley IronPigs: SP Cal Brunsberg was designated for assignment. |
| Wednesday, June 22nd , 2022 |
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| Syracuse Chiefs: Placed RP Kyle Cartwright on the 7-day injured list, retroactive to 06/20/2022. |
| Tuesday, June 21st , 2022 |
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| Lehigh Valley IronPigs: Released LF Jon Dukes. |
| Lehigh Valley IronPigs: Released RP Ryan Frey. |
| Wednesday, May 25th , 2022 |
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| Syracuse Chiefs: Activated RP Dave Turner from the injured list. |
| Gwinnett Stripers: Fired Manager Jorge Cantu. |
| Gwinnett Stripers: Signed Manager Alfredo Simon. |
| Friday, April 29th , 2022 |
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| Syracuse Chiefs: Placed RP Dave Turner on the 7-day injured list, retroactive to 04/28/2022. |
| Tuesday, April 12th , 2022 |
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| Lehigh Valley IronPigs: Released C Greg Marks. |
| Lehigh Valley IronPigs: Released SS Rod Campbell. |
| Tuesday, March 8th , 2022 |
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| Syracuse Chiefs: Placed RP Mike Ridell on the 7-day injured list, retroactive to 03/05/2022. |
| Sunday, February 13th , 2022 |
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| Syracuse Chiefs: Activated RP Mike Ridell from the injured list. |
| Syracuse Chiefs: Activated RP Johnny Garland from the injured list. |
| Thursday, January 27th , 2022 |
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| Syracuse Chiefs: Activated RP Mike Ridell from the injured list. |
| Wednesday, January 26th , 2022 |
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| Syracuse Chiefs: Activated RP Mike Ridell from the injured list. |
| Tuesday, January 18th , 2022 |
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| Syracuse Chiefs: RP Bryan Escanio becomes a free-agent. |
| Friday, December 17th , 2021 |
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| Columbus Clippers: Signed Manager Derin McMains. |
| Thursday, December 9th , 2021 |
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| Norfolk Tides: Signed Manager Alfredo Pedrique. |
| Saturday, December 4th , 2021 |
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| Durham Bulls: Signed Manager Chad Holbrook. |
| Tuesday, November 30th , 2021 |
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| Scranton WB RailRiders: Signed Manager Don Mattingly. |
| Saturday, November 20th , 2021 |
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| Norfolk Tides: 1B Allen Jacobs becomes a free-agent. |
| Norfolk Tides: 1B Dan Black becomes a free-agent. |
| Pawtucket Red Sox: RP Chris Beck becomes a free-agent. |
| Pawtucket Red Sox: 1B Alex Dickerson becomes a free-agent. |
| Durham Bulls: 2B Stanley Mills becomes a free-agent. |
| Toledo Mud Hens: 3B Isacco Sico becomes a free-agent. |
| Toledo Mud Hens: 1B Tyler Bortnick becomes a free-agent. |
| Rochester Red Wings: 2B Julio A. Torres becomes a free-agent. |
| Rochester Red Wings: 3B Jose Rosario becomes a free-agent. |
| Rochester Red Wings: 2B Tim Hampton becomes a free-agent. |
| Gwinnett Stripers: 2B Erik Lee becomes a free-agent. |
| Lehigh Valley IronPigs: C Tom Murphy becomes a free-agent. |
| Syracuse Chiefs: CF Jong-your Paek becomes a free-agent. |
| Syracuse Chiefs: RP Cole Swanson becomes a free-agent. |
| Louisville Bats: 3B Kolbrin Vitek becomes a free-agent. |
| Louisville Bats: LF Brent Bowman becomes a free-agent. |
| Louisville Bats: 1B Nick Delmonico becomes a free-agent. |
| Thursday, November 18th , 2021 |
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| Gwinnett Stripers: Signed Manager Jorge Cantu. |
| Wednesday, November 3rd , 2021 |
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| Scranton WB RailRiders: 1B Chris Robinson retired from professional baseball. |
| Rochester Red Wings: C Melvin Mro retired from professional baseball. |
| Columbus Clippers: RF Gerald Patrick retired from professional baseball. |
| Buffalo Bisons: RP Drew Carpenter retired from professional baseball. |
| Toledo Mud Hens: 3B Andrew Romine retired from professional baseball. |
| Scranton WB RailRiders: RP Chance Fontanez retired from professional baseball. |
| Charlotte Knights: C Jorge Alfaro retired from professional baseball. |
| Columbus Clippers: LF Shojiro Koike retired from professional baseball. |
| Columbus Clippers: RP Raúl Maestas retired from professional baseball. |
| Gwinnett Stripers: RP Craig Bennigson retired from professional baseball. |
| Charlotte Knights: LF Brandon Short retired from professional baseball. |
| Columbus Clippers: SP Markus Hyde retired from professional baseball. |
| Charlotte Knights: SP Rubby de la Rosa retired from professional baseball. |
| Scranton WB RailRiders: SP Anthony Fernandez retired from professional baseball. |
| Charlotte Knights: 3B Brandon Drury retired from professional baseball. |
| Charlotte Knights: RP Todd Kibby retired from professional baseball. |
| Columbus Clippers: 2B Steve Cox retired from professional baseball. |
| Charlotte Knights: SP Braden Shull retired from professional baseball. |
| Pawtucket Red Sox: 2B Kenny Diekroeger retired from professional baseball. |
| Charlotte Knights: RP Nick Travieso retired from professional baseball. |
| Charlotte Knights: 3B Martín Salgado retired from professional baseball. |
| Indianapolis Indians: 3B Sergio Díaz retired from professional baseball. |
| Louisville Bats: RP Owen Murphy retired from professional baseball. |
| Norfolk Tides: Manager Aaron Boone leaves the team, his contract was not renewed |
| Pawtucket Red Sox: Pitching Coach Jim Hickey leaves the team, his contract was not renewed |
| Columbus Clippers: Manager Bobby Crosby leaves the team, his contract was not renewed |
| Columbus Clippers: Pitching Coach Jake Peavy leaves the team, his contract was not renewed |
| Gwinnett Stripers: Pitching Coach Guillermo Mota leaves the team, his contract was not renewed |
| Gwinnett Stripers: Manager Mike Sarbaugh leaves the team, his contract was not renewed |
| Lehigh Valley IronPigs: Pitching Coach Hideyoshi Wada leaves the team, his contract was not renewed |
| Friday, October 8th , 2021 |
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| Columbus Clippers: Signed Hitting Coach David Ortiz to a 2-year contract extension. |
| Monday, September 27th , 2021 |
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| Columbus Clippers: SP Brandon Morrow retires. |
| Rochester Red Wings: SP Joba Chamberlain retires. |
| Toledo Mud Hens: CF Peter Bourjos retires. |
| Durham Bulls: PC Jeff Andrews retires. |
