| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Dupee Shaw | LAA | KC | May 15, 2069 | 8-0 | 9.0 | 0 | 0 | 0 | 0 | 14 | 108 |
| 2 | George Winter | NYM | SD | April 21, 2069 | 1-0 | 9.2 | 0 | 3 | 0 | 1 | 11 | 101 |
| 3 | Matt Harvey | CHC | NAS | April 7, 2069 | 1-0 | 9.0 | 0 | 1 | 0 | 1 | 11 | 101 |
| 4 | Masashi Nakamura | CWS | KC | April 26, 2069 | 3-0 | 9.0 | 0 | 0 | 0 | 1 | 9 | 101 |
| 5 | Andy Coakley | NAS | LAD | Aug. 23, 2069 | 8-0 | 9.0 | 0 | 2 | 0 | 0 | 10 | 100 |
| 6 | Alex Kellner | MIN | LAD | Aug. 30, 2069 | 8-0 | 9.0 | 0 | 1 | 0 | 1 | 10 | 100 |
| 7 | Charlie Sweeney | SF | STL | June 17, 2069 | 8-0 | 9.0 | 0 | 2 | 0 | 0 | 9 | 99 |
| 8 | Ed Walsh | SD | MIL | Sept. 20, 2069 | 3-0 | 9.0 | 0 | 2 | 0 | 1 | 10 | 98 |
| 9 | Harry Howell | BAL | HOU | June 30, 2069 | 16-0 | 9.0 | 0 | 4 | 0 | 1 | 13 | 97 |
| 10 | Denny Lemaster | BOS | HOU | Sept. 21, 2069 | 4-0 | 9.0 | 0 | 3 | 0 | 0 | 9 | 97 |
| 11 | Tony Gonsolin | STL | ATL | April 25, 2069 | 2-0 | 9.0 | 0 | 2 | 0 | 0 | 6 | 96 |
| 12 | Drew Pomeranz | ATL | SEA | July 1, 2069 | 3-0 | 9.0 | 0 | 1 | 0 | 1 | 6 | 96 |
| 13 | Brad Penny | BOS | SEA | May 3, 2069 | 7-0 | 9.0 | 0 | 2 | 0 | 0 | 6 | 96 |
| 14 | Greg Maddux | COL | MIN | Aug. 26, 2069 | 18-0 | 9.0 | 0 | 5 | 0 | 1 | 13 | 95 |
| 15 | Michael Wacha | STL | TEX | Aug. 29, 2069 | 7-0 | 9.0 | 0 | 3 | 0 | 1 | 9 | 95 |
| 16 | Francisco Liriano | MIL | NYM | April 17, 2069 | 3-1 | 8.0 | 0 | 2 | 0 | 1 | 12 | 94 |
| 17 | Nathan Eovaldi | MIN | SEA | Sept. 17, 2069 | 3-0 | 9.0 | 0 | 4 | 0 | 1 | 10 | 94 |
| 18 | Joe Corbett | LAA | KC | Sept. 23, 2069 | 5-1 | 10.0 | 1 | 6 | 0 | 1 | 11 | 94 |
| 19 | Brad Penny | BOS | HOU | May 24, 2069 | 4-0 | 9.0 | 0 | 2 | 0 | 2 | 8 | 94 |
| 20 | Eddie Smith | SF | KC | June 3, 2069 | 7-0 | 9.0 | 0 | 2 | 0 | 3 | 10 | 94 |
| 21 | Rich Harden | DET | LAA | May 23, 2069 | 12-0 | 8.1 | 0 | 2 | 0 | 3 | 14 | 94 |
| 22 | Sandy Koufax | SF | STL | May 14, 2069 | 5-0 | 8.1 | 0 | 3 | 0 | 1 | 11 | 93 |
| 23 | Earl Moore | NAS | SF | June 14, 2069 | 1-0 | 9.0 | 0 | 5 | 0 | 1 | 11 | 93 |
| 24 | Matt Harvey | CHC | STL | Sept. 2, 2069 | 4-0 | 9.0 | 0 | 4 | 0 | 1 | 9 | 93 |
| 25 | Denny Lemaster | BOS | TEX | April 21, 2069 | 6-0 | 9.0 | 0 | 3 | 0 | 3 | 11 | 93 |
| 26 | Jorge de la Rosa | SD | BOS | July 3, 2069 | 6-0 | 8.1 | 0 | 4 | 0 | 1 | 13 | 93 |
| 27 | Bob Miller | MIL | BOS | May 8, 2069 | 1-0 | 8.0 | 0 | 2 | 0 | 0 | 8 | 92 |
| 28 | Ernesto Guereca | CWS | PIT | May 7, 2069 | 3-4 | 8.0 | 0 | 1 | 0 | 2 | 10 | 92 |
| 29 | Joe Corbett | LAA | ATL | May 6, 2069 | 1-0 | 8.1 | 0 | 2 | 0 | 2 | 10 | 92 |
| 30 | Rudy May | PHI | STL | Sept. 19, 2069 | 2-0 | 7.1 | 0 | 2 | 0 | 0 | 12 | 92 |