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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Date | Player | Strikeouts | |
|---|---|---|---|
| 08/03/2017 | Ricardo Sanchez | 15 K, 2 BB and 7.0 IP versus Northern Division while playing for Carolina | |
| 07/28/2023 | Steve Hoover | 15 K, 3 BB and 7.0 IP versus Wilmington while playing for Myrtle Beach | |
| 05/16/2025 | José Vázquez | 15 K, 1 BB and 8.1 IP versus Potomac while playing for Winston-Salem | |
| 08/06/2025 | Mario Manuel | 15 K, 3 BB and 6.0 IP versus Myrtle Beach while playing for Frederick |
