| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Nolan Jones | CHW | COL | April 24, 2022 | 16-6 | 6 | 5 | 9 | 2 | 4 | 0 | 137 |
| 2 | Joey Votto | CHC | SF | April 8, 2022 | 21-1 | 4 | 3 | 9 | 2 | 4 | 3 | 136 |
| 3 | Shohei Ohtani | NYY | HOU | May 28, 2022 | 12-6 | 4 | 4 | 7 | 3 | 4 | 0 | 124 |
| 4 | Jesse Winker | STL | CHW | July 22, 2022 | 10-6 | 4 | 4 | 6 | 3 | 4 | 1 | 122 |
| 5 | Jake Cronenworth | STL | SEA | June 13, 2022 | 11-2 | 4 | 4 | 5 | 2 | 4 | 1 | 110 |
| 6 | Freddie Freeman | ATL | WAS | May 29, 2022 | 15-1 | 5 | 5 | 6 | 1 | 3 | 0 | 108 |
| 7 | Fernando Tatis Jr. | TEX | COL | April 11, 2022 | 12-3 | 6 | 5 | 4 | 3 | 4 | 0 | 107 |
| 8 | Andrew Benintendi | BOS | COL | July 27, 2022 | 19-3 | 6 | 4 | 6 | 1 | 4 | 1 | 104 |
| 9 | Mauricio Dubon | TOR | WAS | June 10, 2022 | 16-5 | 5 | 4 | 7 | 2 | 2 | 0 | 101 |
| 10 | Eloy Jimenez | NYM | HOU | April 6, 2022 | 6-4 | 5 | 4 | 4 | 3 | 4 | 0 | 99 |
| 11 | Nolan Arenado | SF | CHW | July 18, 2022 | 11-1 | 4 | 3 | 6 | 3 | 3 | 0 | 98 |
| 12 | Sam Hilliard | TOR | BOS | April 8, 2022 | 11-3 | 4 | 3 | 6 | 2 | 3 | 1 | 98 |
| 13 | Adley Rutschman | TEX | LAD | May 27, 2022 | 17-7 | 6 | 4 | 5 | 2 | 4 | 0 | 97 |
| 14 | Andrew Vaughn | BOS | TOR | July 23, 2022 | 15-1 | 5 | 3 | 8 | 2 | 2 | 0 | 96 |
| 15 | Corey Seager | BOS | PHI | May 22, 2022 | 20-6 | 5 | 3 | 7 | 1 | 3 | 1 | 96 |
| 16 | Kyle Tucker | ATL | WAS | July 2, 2022 | 14-8 | 5 | 3 | 5 | 2 | 4 | 1 | 94 |
| 17 | Victor Reyes | COL | SD | May 28, 2022 | 11-5 | 4 | 3 | 7 | 2 | 2 | 0 | 93 |
| 18 | Seiya Suzuki | PHI | NYM | July 22, 2022 | 13-1 | 5 | 5 | 3 | 2 | 3 | 0 | 92 |
| 19 | Kris Bryant | SD | CHW | July 20, 2022 | 10-1 | 4 | 3 | 5 | 2 | 3 | 1 | 91 |
| 20 | Austin Barnes | COL | STL | April 1, 2022 | 9-21 | 4 | 3 | 5 | 2 | 3 | 1 | 91 |
| 21 | Eloy Jimenez | NYM | WAS | May 24, 2022 | 12-2 | 5 | 4 | 7 | 1 | 1 | 0 | 89 |
| 22 | Bryan Reynolds | STL | COL | May 6, 2022 | 15-4 | 3 | 2 | 4 | 2 | 4 | 2 | 88 |
| 23 | Freddie Freeman | ATL | HOU | June 17, 2022 | 16-7 | 3 | 3 | 5 | 2 | 2 | 1 | 88 |
| 24 | Kyle Tucker | ATL | SEA | May 30, 2022 | 19-1 | 6 | 3 | 7 | 1 | 3 | 0 | 87 |
| 25 | Cody Bellinger | BOS | TOR | July 24, 2022 | 18-2 | 5 | 4 | 4 | 1 | 3 | 1 | 87 |
| 26 | Brandon Lowe | CHC | SF | April 8, 2022 | 21-1 | 5 | 3 | 5 | 2 | 3 | 1 | 87 |
| 27 | Nolan Gorman | CHC | CHW | April 3, 2022 | 8-2 | 4 | 3 | 6 | 2 | 2 | 0 | 86 |
| 28 | Jesse Winker | STL | LAA | June 7, 2022 | 11-3 | 3 | 3 | 4 | 2 | 2 | 2 | 86 |
| 29 | Seth Beer | MIA | CHW | May 10, 2022 | 14-6 | 4 | 3 | 5 | 1 | 3 | 1 | 86 |
| 30 | Bryan Reynolds | STL | COL | April 1, 2022 | 21-9 | 6 | 4 | 5 | 1 | 3 | 0 | 85 |