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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| Dustin Saenz | 2021-2021 | .000 | 0 | 0 | 1 | 4 | 0 | 5.48 | 37 |
| Jose Salas | 2021-2021 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Lolo Sanchez | 2021-2021 | .271 | 1 | 18 | 0 | 0 | 0 | 0.00 | 0 |
| Rodolfo Sanchez | 2021-2021 | .000 | 0 | 0 | 3 | 0 | 0 | 2.45 | 39 |
| Junior Sanquintin | 2021-2021 | .251 | 7 | 26 | 0 | 0 | 0 | 0.00 | 0 |
| Andy Santana | 2021-2021 | .000 | 0 | 0 | 1 | 0 | 0 | 3.98 | 26 |
| Cristian Santana | 2021-2021 | .157 | 4 | 10 | 0 | 0 | 0 | 0.00 | 0 |
| Debby Santana | 2021-2021 | .237 | 7 | 21 | 0 | 0 | 0 | 0.00 | 0 |
| Rayner Santana | 2021-2021 | .252 | 1 | 10 | 0 | 0 | 0 | 0.00 | 0 |
| Yeison Santana | 2021-2021 | .194 | 2 | 4 | 0 | 0 | 0 | 0.00 | 0 |
| Juan Santander | 2021-2021 | .211 | 1 | 9 | 0 | 0 | 0 | 0.00 | 0 |
| Reid Schaller | 2021-2021 | .000 | 0 | 0 | 1 | 5 | 0 | 3.83 | 39 |
| Alex Scherff | 2021-2021 | .000 | 0 | 0 | 1 | 2 | 0 | 3.43 | 57 |
| Christian Scott | 2021-2021 | .000 | 0 | 0 | 2 | 2 | 0 | 3.46 | 51 |
| Brock Selvidge | 2021-2021 | .000 | 0 | 0 | 2 | 0 | 1 | 1.77 | 14 |
| Emmet Sheehan | 2021-2021 | .000 | 0 | 0 | 1 | 5 | 0 | 3.04 | 40 |
| Avery Short | 2021-2021 | .167 | 0 | 1 | 0 | 2 | 1 | 5.18 | 13 |
| Eric Silva | 2021-2021 | .000 | 0 | 0 | 3 | 4 | 0 | 3.30 | 22 |
| Kendall Simmons | 2021-2021 | .209 | 7 | 24 | 0 | 0 | 0 | 0.00 | 0 |
| Deandre Smith | 2021-2021 | .246 | 1 | 7 | 0 | 0 | 0 | 0.00 | 0 |
| Dylan Smith | 2021-2021 | .000 | 0 | 0 | 1 | 0 | 1 | 1.38 | 38 |
| AJ Smith-Shawver | 2021-2021 | .000 | 0 | 0 | 1 | 2 | 1 | 7.79 | 41 |
| Anthony Solometo | 2021-2021 | .000 | 0 | 0 | 3 | 3 | 0 | 5.08 | 39 |
| Jared Solomon | 2021-2021 | .000 | 0 | 0 | 0 | 0 | 0 | 2.08 | 34 |
| Alex Speas | 2021-2021 | .000 | 0 | 0 | 2 | 0 | 11 | 3.92 | 35 |
| Liam Spence | 2021-2021 | .231 | 5 | 26 | 0 | 0 | 0 | 0.00 | 0 |
| Ryan Spikes | 2021-2021 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Garrett Stallings | 2021-2021 | .000 | 0 | 0 | 2 | 3 | 0 | 3.00 | 26 |
| Adam Stauffer | 2021-2021 | .000 | 0 | 0 | 1 | 1 | 0 | 2.98 | 44 |
| Jacob Steinmetz | 2021-2021 | .000 | 0 | 0 | 0 | 5 | 0 | 6.80 | 18 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Gavin Stone | 2021-2021 | .000 | 0 | 0 | 0 | 0 | 1 | 5.23 | 34 |
| Spencer Strider | 2021-2021 | .000 | 0 | 0 | 1 | 6 | 0 | 4.86 | 44 |
| Alexander Suarez | 2021-2021 | .238 | 2 | 13 | 0 | 0 | 0 | 0.00 | 0 |
| Joander Suarez | 2021-2021 | .000 | 0 | 0 | 2 | 4 | 0 | 2.80 | 53 |
| Ryan Sublette | 2021-2021 | .000 | 0 | 0 | 1 | 2 | 0 | 2.43 | 35 |
| Adrian Sugastey | 2021-2021 | .103 | 0 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| Sean Sullivan | 2021-2021 | .000 | 0 | 0 | 0 | 0 | 0 | 4.76 | 8 |
| Nick Swiney | 2021-2021 | .000 | 0 | 0 | 3 | 2 | 0 | 3.26 | 48 |
