| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sergio Padro | CIN | PIT | Sept. 1, 2045 | 14-1 | 5 | 5 | 7 | 3 | 5 | 0 | 139 |
| 2 | Sean Roberts | MIN | CIN | July 18, 2045 | 7-8 | 4 | 4 | 6 | 4 | 4 | 1 | 127 |
| 3 | Johnny Cowen | SD | COL | April 23, 2045 | 17-2 | 6 | 6 | 4 | 2 | 5 | 0 | 121 |
| 4 | Arturo Vera | BOS | BAL | May 24, 2045 | 11-10 | 5 | 4 | 7 | 3 | 4 | 0 | 120 |
| 5 | Brad Baker | MIL | PIT | May 24, 2045 | 10-4 | 5 | 4 | 9 | 2 | 2 | 0 | 115 |
| 6 | Sergio Contreras | COL | TEX | Aug. 21, 2045 | 17-6 | 5 | 5 | 4 | 2 | 5 | 0 | 113 |
| 7 | Dave Gainey | ARI | BOS | May 28, 2045 | 20-6 | 5 | 4 | 6 | 2 | 4 | 0 | 108 |
| 8 | Jorge Vargas | LAD | COL | Aug. 15, 2045 | 13-2 | 5 | 4 | 7 | 2 | 3 | 0 | 108 |
| 9 | Sergio Padro | CIN | COL | July 8, 2045 | 30-7 | 6 | 5 | 3 | 2 | 5 | 1 | 107 |
| 10 | Abel Manzanares | ARI | PIT | May 18, 2045 | 19-2 | 5 | 5 | 5 | 1 | 3 | 1 | 106 |
| 11 | Chris Ray | SEA | DET | Aug. 26, 2045 | 8-9 | 5 | 5 | 5 | 2 | 3 | 0 | 106 |
| 12 | Sergio Balderrama | KC | CLE | July 21, 2045 | 13-1 | 4 | 3 | 7 | 2 | 3 | 1 | 105 |
| 13 | Greg Adams | SF | COL | May 14, 2045 | 17-5 | 6 | 4 | 7 | 2 | 3 | 0 | 104 |
| 14 | Arturo Vera | BOS | CWS | July 14, 2045 | 11-4 | 4 | 4 | 5 | 2 | 3 | 1 | 103 |
| 15 | Andy Jones | BAL | ARI | July 26, 2045 | 11-4 | 4 | 3 | 6 | 3 | 3 | 1 | 103 |
| 16 | Bobby Cornford | NYY | HOU | May 10, 2045 | 11-5 | 4 | 3 | 6 | 3 | 3 | 1 | 103 |
| 17 | Bobby Cornford | NYY | KC | Aug. 8, 2045 | 13-3 | 4 | 3 | 6 | 2 | 3 | 2 | 103 |
| 18 | Jamie Paulovich | SF | ARI | April 11, 2045 | 8-10 | 4 | 4 | 5 | 2 | 3 | 1 | 103 |
| 19 | Luis Rojas | PHI | CHC | June 27, 2045 | 17-4 | 5 | 3 | 7 | 2 | 3 | 1 | 101 |
| 20 | Steve Chandler | PHI | SF | Aug. 22, 2045 | 13-6 | 3 | 3 | 5 | 2 | 3 | 2 | 100 |
| 21 | Nate Lackey | NYY | BAL | April 22, 2045 | 17-3 | 5 | 5 | 4 | 1 | 3 | 1 | 99 |
| 22 | Curt McKee | LAA | SEA | May 8, 2045 | 14-2 | 4 | 4 | 5 | 2 | 3 | 0 | 98 |
| 23 | Juan San Miguel | CWS | OAK | Aug. 15, 2045 | 11-0 | 4 | 3 | 6 | 3 | 3 | 0 | 98 |
| 24 | Lupe Pacheco | ARI | TOR | July 17, 2045 | 9-7 | 4 | 3 | 6 | 3 | 3 | 0 | 98 |
| 25 | Jon Murphy | BAL | COL | July 16, 2045 | 18-0 | 6 | 5 | 4 | 1 | 4 | 0 | 97 |
| 26 | Esteban Abarca | HOU | NYY | June 28, 2045 | 12-1 | 2 | 2 | 3 | 2 | 5 | 3 | 97 |
| 27 | Kevin Harms | MIL | KC | May 6, 2045 | 9-4 | 3 | 3 | 5 | 2 | 3 | 1 | 95 |
| 28 | Steve Ruppel | OAK | BAL | July 21, 2045 | 11-9 | 3 | 3 | 6 | 2 | 2 | 1 | 95 |
| 29 | Mike Buchanan | CHC | SD | June 4, 2045 | 5-4 | 7 | 5 | 3 | 3 | 3 | 1 | 94 |
| 30 | Kevin Russell | KC | OAK | Aug. 22, 2045 | 14-4 | 3 | 3 | 3 | 2 | 4 | 2 | 93 |