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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | G | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Addison Reed# | 770 | 2012-2024 | |
| 2 | Vinnie Pestano# | 760 | 2012-2023 | |
| 3 | Aroldis Chapman# | 753 | 2012-2024 | |
| 4 | Phillippe Aumont# | 722 | 2012-2024 | |
| 5 | Robert Paullus# | 714 | 2013-2024 | |
| 6 | Marc Rzepczynski# | 711 | 2012-2024 | |
| 7 | Daniel Schlereth# | 708 | 2012-2024 | |
| 8 | Arodys Vizcaino# | 706 | 2013-2024 | |
| 9 | Jordan Walden# | 701 | 2012-2024 | |
| 10 | Pasqualino Carosi# | 691 | 2014-2024 | |
| 10 | Hector Santiago# | 691 | 2012-2024 | |
| 12 | Boone Logan | 681 | 2012-2021 | |
| 13 | Shawn Tolleson# | 668 | 2012-2022 | |
| 14 | Bobby Parnell | 652 | 2012-2021 | |
| 15 | Sergio Romo | 646 | 2012-2021 | |
| 16 | Josh Spence | 625 | 2012-2022 | |
| 17 | Kelvin Herrera# | 622 | 2012-2021 | |
| 18 | Mark Melancon | 618 | 2012-2020 | |
| 19 | Brian Wilson | 605 | 2012-2020 | |
| 20 | Kenley Jansen | 591 | 2012-2021 | |
| 21 | Nick McCully# | 590 | 2014-2024 | |
| 22 | Tyler Clippard | 585 | 2012-2021 | |
| 23 | Anthony Bass# | 578 | 2014-2023 | |
| 24 | Javy Guerra | 572 | 2012-2021 | |
| 25 | Casey Mulligan# | 569 | 2013-2021 | |
| 26 | Michael Schwimer | 564 | 2012-2021 | |
| 26 | Jonny Venters | 564 | 2012-2020 | |
| 28 | Craig Kimbrel# | 560 | 2012-2022 | |
| 29 | Enosil Tejeda# | 554 | 2014-2024 | |
| 30 | Yosuke Ichikawa# | 553 | 2014-2023 | |
| 31 | Scott Elbert | 539 | 2012-2020 | |
| 32 | Jorge De Leon | 537 | 2012-2021 | |
| 33 | Fernando Salas | 534 | 2012-2021 | |
| 34 | Hideaki Hirata# | 531 | 2014-2024 | |
| 35 | Fautino de los Santos# | 530 | 2012-2021 | |
| 36 | Matt Nevarez# | 529 | 2014-2024 | |
| 37 | Gabriel Flores# | 526 | 2015-2024 | |
| 38 | Gregory Infante# | 523 | 2012-2021 | |
| 38 | Dan Runzler | 523 | 2012-2020 | |
| 40 | Joel Hanrahan | 521 | 2012-2020 | |
| 41 | Ben Rowen# | 519 | 2014-2024 | |
| 42 | Drew Storen | 516 | 2012-2020 | |
| 43 | J.P. Howell | 509 | 2012-2019 | |
| 44 | Austin Adams | 507 | 2013-2023 | |
| 44 | Jonathan Broxton | 507 | 2012-2019 | |
| 46 | Eric O'Flaherty | 505 | 2012-2020 | |
| 47 | Brandon Creath# | 498 | 2015-2024 | |
| 48 | Ramon Lebron | 493 | 2013-2022 | |
| 49 | Rex Brothers | 492 | 2012-2019 | |
| 50 | Heath Bell | 485 | 2012-2019 | |
| 51 | Rich Thompson | 483 | 2012-2018 | |
| 52 | Jeurys Familia | 479 | 2012-2022 | |
| 53 | John O'Quinn | 477 | 2012-2020 | |
| 53 | Huston Street | 477 | 2012-2019 | |
| 55 | Mark Montgomery# | 476 | 2013-2021 | |
| 56 | Mike Dunn | 475 | 2012-2019 | |
| 57 | Antonio Bastardo | 474 | 2012-2020 | |
| 58 | Krishawn Holley# | 473 | 2015-2024 | |
| 59 | Brian Fuentes | 468 | 2012-2017 | |
| 59 | Michael Morrison# | 468 | 2014-2021 | |
| 61 | Josh Lueke | 462 | 2012-2019 | |
| 62 | Andy Otero# | 457 | 2015-2024 | |
| 63 | Daniel Tillman | 456 | 2015-2023 | |
| 64 | Dennis Moore# | 454 | 2017-2024 | |
| 65 | Carlos Meza# | 451 | 2014-2024 | |
| 66 | Branden Kline# | 448 | 2016-2024 | |
| 66 | Chris Perez | 448 | 2012-2018 | |
| 66 | Tanner Scheppers# | 448 | 2013-2023 | |
| 69 | Jose Arredondo | 447 | 2012-2020 | |
| 70 | Víctor Mejía# | 446 | 2013-2024 | |
| 70 | Koji Uehara | 446 | 2012-2018 | |
| 72 | Bobby Jenks | 443 | 2012-2019 | |
| 72 | Wesley Wright | 443 | 2012-2018 | |
| 74 | Klaas Bongers# | 440 | 2015-2024 | |
| 75 | Lester Oliveros | 436 | 2012-2021 | |
| 76 | Michael Brady# | 431 | 2013-2022 | |
| 77 | Zachary Herr | 428 | 2014-2021 | |
| 78 | Brad Brach# | 423 | 2012-2021 | |
| 79 | Bryan Shaw | 421 | 2015-2020 | |
| 80 | Jimmy Bannatyne# | 419 | 2016-2024 | |
| 80 | Nick Masset | 419 | 2012-2019 | |
| 82 | Bryan Morris | 417 | 2012-2020 | |
| 83 | Brad Peacock | 416 | 2012-2023 | |
| 83 | Tom Wilhelmsen | 416 | 2012-2019 | |
| 85 | Jeremy Affeldt | 413 | 2012-2017 | |
| 86 | Gerrit Cole# | 411 | 2012-2024 | |
| 86 | Boomer Potts | 411 | 2014-2020 | |
| 86 | Jesús Romero | 411 | 2012-2021 | |
| 89 | Hong-Chih Kuo | 405 | 2012-2018 | |
| 90 | Joel Zumaya | 401 | 2013-2018 | |
| 91 | Jonathan Martinez# | 398 | 2015-2021 | |
| 92 | Mark Lowe | 393 | 2012-2018 | |
| 93 | Anthony Meo# | 392 | 2013-2022 | |
| 94 | Michel Roman# | 390 | 2018-2024 | |
| 95 | Tyler Green# | 386 | 2015-2024 | |
| 96 | Zack Greinke# | 385 | 2012-2024 | |
| 96 | Alex Rivers# | 385 | 2012-2021 | |
| 98 | Orlando García# | 381 | 2016-2024 | |
| 99 | Edwin Carl | 379 | 2013-2020 | |
| 100 | Daniel Hudson# | 378 | 2012-2022 |
