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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Clayton Kershaw# | 2668 | 2012-2024 | |
| 2 | Stephen Strasburg# | 2502 | 2012-2024 | |
| 3 | Danny Hultzen# | 2284 | 2012-2024 | |
| 4 | Zack Greinke# | 2236 | 2012-2024 | |
| 5 | Tim Lincecum# | 2228 | 2012-2023 | |
| 6 | Sean Gilmartin# | 2196 | 2012-2024 | |
| 7 | Nathan Eovaldi# | 1990 | 2012-2024 | |
| 8 | Gerrit Cole# | 1968 | 2012-2024 | |
| 9 | Trevor Bauer# | 1879 | 2012-2024 | |
| 10 | Felix Hernandez | 1813 | 2012-2022 | |
| 11 | Brad Peacock | 1803 | 2012-2023 | |
| 12 | Lucas Giolito# | 1776 | 2016-2024 | |
| 13 | Justin Verlander* | 1764 | 2012-2020 | |
| 14 | Keyvius Sampson# | 1763 | 2014-2024 | |
| 15 | Brandon Beachy | 1739 | 2012-2022 | |
| 16 | Josh Johnson | 1602 | 2012-2021 | |
| 17 | Michael Pineda# | 1597 | 2012-2022 | |
| 18 | Mat Latos# | 1579 | 2012-2022 | |
| 19 | Jonathon Niese | 1573 | 2012-2022 | |
| 20 | Josh Collmenter | 1572 | 2012-2022 | |
| 21 | Jon Lester* | 1568 | 2012-2021 | |
| 22 | Tommy Hanson | 1567 | 2012-2020 | |
| 23 | Jordan Lyles# | 1543 | 2012-2023 | |
| 24 | Jordan Zimmermann | 1540 | 2012-2021 | |
| 25 | Alberto Vega# | 1539 | 2016-2024 | |
| 26 | Aroldis Chapman# | 1531 | 2012-2024 | |
| 27 | Jarred Cosart# | 1514 | 2012-2024 | |
| 28 | David Price | 1504 | 2012-2019 | |
| 29 | Madison Bumgarner# | 1503 | 2012-2024 | |
| 30 | Juan Nicasio | 1502 | 2012-2021 | |
| 31 | Phil Hughes | 1493 | 2012-2021 | |
| 32 | Ryan Copeland# | 1466 | 2015-2024 | |
| 33 | Shelby Miller# | 1447 | 2012-2022 | |
| 34 | Yu Darvish | 1429 | 2012-2021 | |
| 35 | Gio Gonzalez | 1425 | 2012-2020 | |
| 36 | Parker Markel# | 1414 | 2014-2024 | |
| 37 | Miguel Pineda# | 1406 | 2016-2024 | |
| 38 | Chris Sale# | 1379 | 2012-2024 | |
| 39 | Max Scherzer | 1360 | 2012-2023 | |
| 40 | Scott Clark# | 1356 | 2015-2022 | |
| 41 | Daniel Hudson# | 1319 | 2012-2022 | |
| 42 | Mark Appel# | 1306 | 2014-2024 | |
| 43 | Archie Bradley# | 1304 | 2015-2024 | |
| 44 | Brandon Morrow | 1303 | 2012-2019 | |
| 45 | Mark Sorensen | 1299 | 2013-2022 | |
| 46 | Carlos Meza# | 1297 | 2014-2024 | |
| 47 | Bill Black# | 1291 | 2017-2024 | |
| 48 | Matt Moore | 1281 | 2012-2020 | |
| 49 | Dylan Bundy# | 1271 | 2012-2023 | |
| 50 | Broderick Wilson# | 1255 | 2016-2024 | |
| 51 | James Paxton# | 1248 | 2012-2023 | |
| 52 | Manuel Reyes# | 1243 | 2014-2024 | |
| 53 | Anthony Meo# | 1239 | 2013-2022 | |
| 54 | Casey Kelly# | 1237 | 2013-2023 | |
| 55 | Raynel Velette# | 1233 | 2015-2024 | |
| 56 | Michael Matuella# | 1218 | 2016-2024 | |
| 57 | Neftali Feliz | 1217 | 2012-2021 | |
| 58 | Kolby Allard# | 1212 | 2018-2024 | |
| 58 | Mike Minor | 1212 | 2012-2018 | |
| 60 | Tyler Pill# | 1201 | 2014-2023 | |
| 61 | Kyle Cody# | 1190 | 2017-2024 | |
| 62 | Trevor Cahill | 1188 | 2012-2022 | |
| 63 | Justin Hooper# | 1187 | 2018-2024 | |
| 64 | Albert Suarez# | 1186 | 2014-2023 | |
| 65 | Zach Lee# | 1185 | 2013-2024 | |
| 65 | Michael Wacha# | 1185 | 2016-2024 | |
| 67 | Josh Tomlin# | 1176 | 2012-2022 | |
| 68 | Brady Aiken# | 1173 | 2017-2024 | |
| 69 | Wilmer Font | 1160 | 2012-2021 | |
| 70 | Manny Banuelos# | 1141 | 2012-2019 | |
| 71 | John Lamb# | 1133 | 2014-2024 | |
| 72 | Sonny Gray# | 1125 | 2012-2022 | |
| 73 | Chris Scalise# | 1105 | 2017-2024 | |
| 74 | Kevin Comer# | 1104 | 2015-2024 | |
| 75 | James Kaprielian# | 1101 | 2016-2024 | |
| 76 | Jeffery LeBlanc# | 1098 | 2018-2024 | |
| 77 | Matt Barnes# | 1086 | 2015-2023 | |
| 78 | Wily Peralta# | 1075 | 2012-2021 | |
| 79 | Matt Cain | 1068 | 2012-2020 | |
| 80 | Walker Buehler# | 1042 | 2017-2024 | |
| 81 | Andrew Morales# | 1039 | 2018-2024 | |
| 82 | Vance Worley | 1028 | 2012-2020 | |
| 83 | Pedro Magana# | 1018 | 2018-2024 | |
| 84 | Jarrod Parker# | 1017 | 2012-2021 | |
| 85 | Richard White# | 1013 | 2017-2024 | |
| 86 | Steven Matz# | 1009 | 2016-2023 | |
| 86 | Tyler Skaggs# | 1009 | 2013-2022 | |
| 88 | Steve White# | 1001 | 2016-2024 | |
| 89 | Jered Weaver | 998 | 2012-2017 | |
| 90 | Craig Cooper# | 996 | 2016-2024 | |
| 91 | Robert Paullus# | 991 | 2013-2024 | |
| 92 | Domingo Tapia | 980 | 2014-2022 | |
| 93 | Mike Montgomery# | 977 | 2012-2024 | |
| 94 | Jordan Cote# | 972 | 2015-2024 | |
| 95 | Marc Rzepczynski# | 971 | 2012-2024 | |
| 96 | Chad Billingsley | 970 | 2012-2020 | |
| 97 | C.J. Wilson | 968 | 2012-2018 | |
| 98 | Vinnie Pestano# | 958 | 2012-2023 | |
| 99 | Jeurys Familia | 957 | 2012-2022 | |
| 100 | Simon Castro# | 954 | 2012-2020 |
