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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aaron O'Day | 2023-2023 | 1 | 0 | 1.000 | 3.49 | 15 | 0 | 0 | 0 | 2 | 28.1 | 23 | 11 | 1 | 20 | 25 |
| Darren O'Day | 2015-2016 | 1 | 2 | .333 | 6.62 | 16 | 0 | 0 | 0 | 0 | 17.2 | 22 | 13 | 2 | 4 | 14 |
| John O'Day | 2015-2017 | 14 | 9 | .609 | 3.84 | 39 | 39 | 0 | 0 | 0 | 208.1 | 220 | 89 | 20 | 75 | 195 |
| Clayton O'Neil | 2023-2023 | 6 | 4 | .600 | 4.88 | 31 | 0 | 0 | 0 | 2 | 27.2 | 35 | 15 | 4 | 14 | 31 |
| John O'Quinn | 2012-2020 | 4 | 4 | .500 | 10.58 | 67 | 0 | 0 | 0 | 8 | 57.0 | 89 | 67 | 10 | 50 | 63 |
| Bruce O'Slattery | 2021-2022 | 2 | 4 | .333 | 5.29 | 61 | 1 | 0 | 0 | 2 | 112.1 | 112 | 66 | 13 | 70 | 89 |
| Sean O'Sullivan | 2012-2018 | 33 | 28 | .541 | 4.38 | 117 | 82 | 1 | 0 | 4 | 575.1 | 605 | 280 | 83 | 127 | 422 |
| Brett Oberholtzer | 2013-2020 | 10 | 9 | .526 | 4.30 | 42 | 31 | 0 | 0 | 1 | 207.0 | 197 | 99 | 29 | 64 | 187 |
| Aaron Oberkfel | 2022-2024 | 0 | 1 | .000 | 4.22 | 11 | 0 | 0 | 0 | 0 | 21.1 | 18 | 10 | 3 | 12 | 17 |
| Jake Odorizzi | 2012-2020 | 3 | 2 | .600 | 4.30 | 8 | 6 | 1 | 0 | 0 | 37.2 | 39 | 18 | 4 | 11 | 33 |
| Alexi Ogando | 2013-2013 | 3 | 2 | .600 | 4.98 | 9 | 6 | 0 | 0 | 1 | 43.1 | 42 | 24 | 4 | 17 | 42 |
| Jefferson Olacio | 2020-2022 | 10 | 9 | .526 | 3.22 | 108 | 3 | 0 | 0 | 8 | 187.1 | 137 | 67 | 6 | 111 | 229 |
| Jason Olbryc | 2023-2023 | 6 | 1 | .857 | 4.33 | 34 | 0 | 0 | 0 | 1 | 70.2 | 74 | 34 | 8 | 41 | 81 |
| Andrew Oliver | 2012-2012 | 1 | 2 | .333 | 3.62 | 5 | 5 | 0 | 0 | 0 | 32.1 | 33 | 13 | 2 | 11 | 28 |
| Lester Oliveros | 2013-2021 | 0 | 6 | .000 | 5.40 | 27 | 0 | 0 | 0 | 13 | 21.2 | 27 | 13 | 2 | 7 | 15 |
| Michael Olmsted | 2013-2021 | 6 | 9 | .400 | 3.91 | 115 | 0 | 0 | 0 | 42 | 119.2 | 115 | 52 | 15 | 57 | 138 |
| Juan Oramas | 2015-2016 | 18 | 23 | .439 | 4.94 | 56 | 56 | 2 | 0 | 0 | 317.0 | 323 | 174 | 40 | 122 | 273 |
| Paul Orr | 2019-2023 | 21 | 19 | .525 | 4.38 | 93 | 59 | 0 | 0 | 4 | 336.2 | 316 | 164 | 27 | 166 | 311 |
| Jesús Ortega | 2022-2022 | 1 | 1 | .500 | 9.24 | 19 | 2 | 0 | 0 | 0 | 12.2 | 21 | 13 | 2 | 11 | 7 |
| Jose Ortega | 2014-2020 | 7 | 7 | .500 | 5.52 | 96 | 0 | 0 | 0 | 16 | 91.1 | 97 | 56 | 14 | 40 | 115 |
| Joseph Ortiz | 2014-2016 | 3 | 3 | .500 | 3.80 | 51 | 0 | 0 | 0 | 7 | 68.2 | 71 | 29 | 8 | 27 | 71 |
| Victor Ortíz | 2018-2022 | 18 | 25 | .419 | 4.29 | 263 | 0 | 0 | 0 | 89 | 247.2 | 262 | 118 | 18 | 105 | 243 |
| Josh Osich | 2016-2021 | 7 | 6 | .538 | 3.03 | 106 | 0 | 0 | 0 | 6 | 130.2 | 135 | 44 | 6 | 44 | 116 |
| Roberto Osuna | 2018-2019 | 4 | 2 | .667 | 3.68 | 34 | 1 | 0 | 0 | 2 | 51.1 | 44 | 21 | 4 | 19 | 68 |
| Andy Otero | 2017-2019 | 2 | 4 | .333 | 5.47 | 15 | 9 | 0 | 0 | 0 | 52.2 | 68 | 32 | 6 | 11 | 37 |
| Tadaaki Otsuka | 2017-2018 | 12 | 13 | .480 | 3.34 | 56 | 33 | 0 | 0 | 2 | 218.1 | 209 | 81 | 21 | 55 | 168 |
| Teo Ottenhof | 2018-2019 | 4 | 2 | .667 | 3.99 | 37 | 0 | 0 | 0 | 2 | 67.2 | 37 | 30 | 6 | 50 | 59 |
| Josh Outman | 2012-2015 | 10 | 15 | .400 | 5.71 | 118 | 18 | 3 | 0 | 2 | 205.0 | 224 | 130 | 24 | 98 | 143 |
| Tyler Owens | 2024-2024 | 1 | 0 | 1.000 | 4.05 | 1 | 1 | 0 | 0 | 0 | 6.2 | 5 | 3 | 2 | 4 | 3 |
