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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| Charles O'Brien | 2020-2022 | .000 | 0 | 0 | 15 | 10 | 0 | 3.38 | 194 |
| Henry O'Day | 2018-2018 | .273 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Will O'Neal | 2024-2024 | .000 | 0 | 0 | 1 | 0 | 0 | 3.60 | 7 |
| Clayton O'Neil | 2021-2021 | .000 | 0 | 0 | 2 | 1 | 22 | 2.51 | 27 |
| Steven O'Toole | 2023-2024 | .306 | 5 | 36 | 0 | 0 | 0 | 0.00 | 0 |
| Aaron Oberkfel | 2021-2023 | .321 | 7 | 67 | 1 | 2 | 12 | 4.37 | 50 |
| Ted Obregon | 2012-2012 | .315 | 2 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Tadanobu Ogawa | 2013-2019 | .313 | 24 | 138 | 0 | 0 | 0 | 0.00 | 0 |
| Michael Ohlman | 2014-2022 | .242 | 9 | 51 | 0 | 0 | 0 | 0.00 | 0 |
| Jefferson Olacio | 2017-2019 | .000 | 0 | 0 | 9 | 8 | 2 | 3.08 | 147 |
| Lester Oliveros | 2012-2012 | .000 | 0 | 0 | 0 | 0 | 1 | 8.22 | 7 |
| Whit Olmstead | 2018-2018 | .293 | 1 | 8 | 0 | 0 | 0 | 0.00 | 0 |
| Michael Olmsted | 2012-2012 | .000 | 0 | 0 | 3 | 0 | 15 | 2.83 | 50 |
| Raymond Olson | 2021-2021 | .274 | 20 | 65 | 0 | 0 | 0 | 0.00 | 0 |
| Shane Opitz | 2015-2015 | .500 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Paulo Orlando | 2013-2013 | .192 | 4 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Jesús Orozco | 2018-2019 | .259 | 10 | 73 | 0 | 0 | 0 | 0.00 | 0 |
| Paul Orr | 2020-2020 | .000 | 0 | 0 | 2 | 3 | 0 | 3.74 | 39 |
| César Ortega | 2022-2023 | .301 | 4 | 24 | 0 | 0 | 0 | 0.00 | 0 |
| Gabriel Ortega | 2023-2024 | .234 | 1 | 15 | 0 | 0 | 0 | 0.00 | 0 |
| Jose Ortega | 2012-2016 | .000 | 0 | 0 | 0 | 2 | 4 | 8.13 | 36 |
| José Ortega | 2021-2022 | .220 | 8 | 40 | 0 | 0 | 0 | 0.00 | 0 |
| Juan Ortega | 2022-2023 | .236 | 18 | 111 | 0 | 0 | 0 | 0.00 | 0 |
| Daniel Ortiz | 2012-2012 | .248 | 3 | 18 | 0 | 0 | 0 | 0.00 | 0 |
| Evan Osborne | 2024-2024 | .243 | 3 | 6 | 0 | 0 | 0 | 0.00 | 0 |
| Josh Osich | 2013-2016 | .000 | 0 | 0 | 6 | 7 | 4 | 5.34 | 132 |
| Tyson Oswalt | 2020-2020 | .000 | 0 | 0 | 5 | 2 | 0 | 2.15 | 85 |
| Miguel Otero | 2020-2023 | .277 | 16 | 149 | 0 | 0 | 0 | 0.00 | 0 |
| Tadaaki Otsuka | 2019-2021 | .000 | 0 | 0 | 18 | 9 | 9 | 3.19 | 180 |
| Matt Owen | 2020-2020 | .222 | 5 | 20 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Richard Owens | 2016-2021 | .000 | 0 | 0 | 14 | 5 | 34 | 3.85 | 92 |
| Tyler Owens | 2022-2023 | .000 | 0 | 0 | 10 | 10 | 0 | 4.13 | 204 |
| Jun'ichi Ozaki | 2014-2023 | .000 | 0 | 0 | 9 | 18 | 67 | 3.69 | 189 |
| Marcell Ozuna | 2016-2016 | .228 | 6 | 19 | 0 | 0 | 0 | 0.00 | 0 |
