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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| Patrick O'Brien | 2019-2019 | .000 | 0 | 0 | 5 | 0 | 0 | 3.64 | 33 |
| Shane O'Connor | 2021-2022 | .206 | 1 | 9 | 0 | 0 | 0 | 0.00 | 0 |
| Jamal O'Guinn | 2021-2021 | .233 | 3 | 6 | 0 | 0 | 0 | 0.00 | 0 |
| Bryan O'Halloran | 2022-2022 | .000 | 0 | 0 | 1 | 1 | 0 | 3.06 | 19 |
| John O'Herlihy | 2019-2020 | .343 | 1 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Clayton O'Neil | 2019-2019 | .000 | 0 | 0 | 1 | 0 | 2 | 3.00 | 3 |
| Steven O'Toole | 2020-2020 | .250 | 1 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Ted Obregon | 2012-2012 | .400 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Carlos Ochoa | 2017-2017 | .200 | 1 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Pedro Ochoa | 2019-2019 | .218 | 3 | 21 | 0 | 0 | 0 | 0.00 | 0 |
| Jake Odorizzi | 2020-2020 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 1 |
| Tadanobu Ogawa | 2012-2012 | .287 | 8 | 35 | 0 | 0 | 0 | 0.00 | 0 |
| Braeden Ogle | 2020-2021 | .000 | 0 | 0 | 1 | 4 | 1 | 4.38 | 30 |
| Roberto Oliva | 2018-2020 | .000 | 0 | 0 | 1 | 8 | 0 | 5.19 | 97 |
| Joaquín Olivencio | 2018-2019 | .000 | 0 | 0 | 4 | 0 | 1 | 2.40 | 22 |
| José Olivo | 2016-2021 | .265 | 1 | 2 | 1 | 2 | 1 | 5.06 | 105 |
| Munemitsu Ono | 2020-2020 | .000 | 0 | 0 | 3 | 2 | 2 | 7.11 | 16 |
| Jesús Orozco | 2017-2017 | .071 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Paul Orr | 2016-2016 | .206 | 1 | 3 | 5 | 7 | 0 | 3.12 | 97 |
| Gabriel Ortega | 2019-2019 | .261 | 2 | 20 | 0 | 0 | 0 | 0.00 | 0 |
| Jesús Ortega | 2018-2018 | .000 | 0 | 0 | 1 | 1 | 0 | 1.86 | 40 |
| José Ortega | 2017-2017 | .229 | 0 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Domingo Ortíz | 2019-2022 | .290 | 49 | 188 | 0 | 0 | 0 | 0.00 | 0 |
| Edgardo Ortíz | 2022-2022 | .248 | 2 | 12 | 1 | 0 | 0 | 1.84 | 21 |
| José Ortíz | 2022-2022 | .273 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Ramón Ortíz | 2014-2015 | .236 | 9 | 24 | 0 | 0 | 0 | 0.00 | 0 |
| Sergio Ortíz | 2018-2019 | .000 | 0 | 0 | 6 | 9 | 0 | 3.15 | 97 |
| Roberto Osuna | 2013-2013 | .000 | 0 | 0 | 6 | 5 | 0 | 6.19 | 63 |
| Tyson Oswalt | 2018-2018 | .000 | 0 | 0 | 7 | 4 | 0 | 2.89 | 70 |
| Alberto Otero | 2019-2020 | .000 | 0 | 0 | 5 | 6 | 0 | 4.40 | 131 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Miguel Otero | 2018-2018 | .317 | 1 | 22 | 0 | 0 | 0 | 0.00 | 0 |
| Pancho Otero | 2021-2022 | .000 | 0 | 0 | 4 | 7 | 0 | 4.31 | 76 |
| Micah Ottenbreit | 2022-2022 | .000 | 0 | 0 | 1 | 3 | 0 | 3.45 | 22 |
| Teo Ottenhof | 2016-2017 | .000 | 0 | 0 | 0 | 2 | 15 | 2.38 | 32 |
| Josh Outman | 2013-2013 | .000 | 0 | 0 | 1 | 2 | 3 | 2.62 | 36 |
