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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sa, Peng | SP | Tennessee Smokies | 26 | 06/05/2045 | Saskatoon | CAN | Right | Right | 6' 4" | 200 lbs | - |
| Salazar, Carlos | RP | Jackson Generals | 25 | 11/25/2045 | Cancún | MEX | Right | Right | 6' 4" | 200 lbs | - |
| Sampson, Brandon | C | Chattanooga Lookouts | 29 | 07/05/2042 | Aurora | USA | Switch | Right | 5' 10" | 200 lbs | - |
| Santiago, Roberto | RP | Carolina Mudcats | 25 | 11/21/2045 | Santiago de Cuba | CUB | Left | Right | 6' 4" | 200 lbs | - |
| Santos, Albert | RP | Birmingham Barons | 27 | 06/28/2044 | Santiago de Cuba | CUB | Right | Right | 6' 2" | 195 lbs | - |
| Santos, Jaime | LF | Mississippi Braves | 28 | 12/18/2042 | Managua | NCA | Right | Right | 6' 4" | 200 lbs | - |
| Santos, Miguel | 1B | Mobile Bay Bears | 27 | 12/12/2043 | Santo Domingo | DOM | Left | Right | 6' 3" | 200 lbs | $500,000 |
| Saunders, Derek | RP | Carolina Mudcats | 25 | 12/20/2045 | Nurillo | USA | Right | Right | 6' 5" | 200 lbs | - |
| Schoendienst, Chad | SP | Chattanooga Lookouts | 28 | 12/27/2042 | Southlake | USA | Switch | Right | 5' 10" | 200 lbs | - |
| Schroeder, Dan | SP | Mobile Bay Bears | 23 | 03/12/2048 | Waterloo | USA | Switch | Right | 6' 0" | 190 lbs | - |
| Scott, Don | CL | Tennessee Smokies | 25 | 04/12/2046 | Cambridge | CAN | Right | Left | 6' 4" | 200 lbs | - |
| Scott, Rusty | 3B | Carolina Mudcats | 26 | 05/01/2045 | Pueblo West | USA | Right | Right | 6' 1" | 195 lbs | - |
| Shang, Ling-kung | RP | Birmingham Barons | 26 | 02/11/2045 | Homei | TPE | Left | Left | 6' 1" | 180 lbs | - |
| Shields, Jeff | RP | Carolina Mudcats | 24 | 10/06/2046 | New York | USA | Right | Right | 6' 3" | 200 lbs | - |
| Shu, Ai-de | DH | Carolina Mudcats | 23 | 09/24/2047 | Beijing | CHN | Left | Right | 6' 6" | 200 lbs | - |
| Silva, Roberto | RF | Chattanooga Lookouts | 27 | 01/11/2044 | David | PAN | Right | Right | 6' 4" | 205 lbs | - |
| Simpson, Christian | RP | Jacksonville Suns | 28 | 08/29/2042 | Pearl River | USA | Left | Left | 6' 1" | 200 lbs | - |
| Smart, Drew | SP | Free Agent | 28 | 02/25/2043 | Iowa City | USA | Left | Left | 6' 5" | 215 lbs | - |
| Smith, Dave | 3B | Mobile Bay Bears | 30 | 07/20/2041 | Creve Coeur | USA | Right | Right | 6' 4" | 200 lbs | - |
| Smith, John | SP | Tennessee Smokies | 23 | 12/18/2047 | Glen Burnie | USA | Left | Left | 6' 3" | 195 lbs | - |
| Snyder, Anthony | SP | Free Agent | 26 | 03/12/2045 | New York | USA | Switch | Right | 6' 2" | 195 lbs | - |
| Soto, José | C | Carolina Mudcats | 24 | 03/24/2047 | Caracas | VEN | Left | Right | 6' 2" | 200 lbs | - |
| Soto, Miguel | RP | Birmingham Barons | 30 | 09/17/2040 | Santiago de Cuba | CUB | Left | Left | 6' 0" | 190 lbs | $6,000,000 |
| Stevens, Ralph | RP | Free Agent | 29 | 04/06/2042 | Scottsdale | USA | Right | Right | 6' 5" | 205 lbs | - |
| Stevens, William | RF | Huntsville Stars | 26 | 06/02/2045 | Queens | USA | Left | Left | 6' 0" | 200 lbs | - |
| Stewart, Clarence | SP | Birmingham Barons | 26 | 03/12/2045 | Fort Collins | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sánchez, Anthony | CF | Huntsville Stars | 26 | 05/19/2045 | Echelon | USA | Left | Left | 6' 1" | 185 lbs | - |
| Sánchez, Juan | LF | Birmingham Barons | 29 | 12/21/2041 | San Juan | PUR | Left | Left | 6' 2" | 200 lbs | - |
| Sánchez, Norberto | CL | Free Agent | 25 | 02/26/2046 | Ecatepec | MEX | Left | Left | 6' 5" | 200 lbs | - |
