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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sai, Masahiko | SP | Free Agent | 33 | 05/04/2038 | Yokohama | JPN | Right | Left | 6' 9" | 200 lbs | - |
| Santos, Ángel | LF | Springfield Cardinals | 26 | 05/04/2045 | Cuernavaca | MEX | Left | Left | 6' 3" | 200 lbs | - |
| Saqr, Abdul-Rahman | SS | Northwest Arkansas Naturals | 27 | 03/24/2044 | Léré | CHA | Right | Right | 6' 3" | 200 lbs | - |
| Scherbarth, Jack | 2B | Free Agent | 24 | 10/08/2046 | Manatí | PUR | Switch | Right | 6' 2" | 200 lbs | - |
| Schum, Jason | C | Northwest Arkansas Naturals | 22 | 01/14/2049 | Hilton Head Island | USA | Right | Right | 6' 5" | 200 lbs | - |
| Scott, Aaron | LF | Springfield Cardinals | 26 | 06/23/2045 | Phoenix | USA | Right | Right | 6' 0" | 195 lbs | - |
| Shelby, Jeff | CL | Tulsa Drillers | 22 | 04/04/2049 | Dallas | USA | Right | Right | 6' 1" | 195 lbs | - |
| Shepard, Alden | SP | Tulsa Drillers | 20 | 11/01/2050 | Park Ridge | USA | Right | Right | 6' 0" | 180 lbs | - |
| Shepard, Oscar | CF | Midland Rock Hounds | 26 | 12/11/2044 | Missouri City | USA | Right | Right | 5' 11" | 190 lbs | - |
| Silva, Gabriel | RP | Free Agent | 25 | 05/21/2046 | Managua | NCA | Switch | Right | 6' 3" | 200 lbs | - |
| Simmons, Artie | 2B | Springfield Cardinals | 24 | 04/04/2047 | Fort Worth | USA | Right | Right | 6' 0" | 185 lbs | - |
| Simpson, Horace | SP | San Antonio Missions | 23 | 06/24/2048 | Ballwin | USA | Right | Right | 5' 10" | 175 lbs | - |
| Smith, Bill | SS | Midland Rock Hounds | 23 | 06/07/2048 | Greene | USA | Right | Right | 6' 4" | 195 lbs | - |
| Smith, Dennis | SP | Frisco Rough Riders | 28 | 06/26/2043 | West Concord | USA | Right | Right | 6' 2" | 195 lbs | - |
| Smith, Forrest | SP | San Antonio Missions | 25 | 03/24/2046 | El Paso | USA | Right | Right | 6' 2" | 200 lbs | - |
| Smith, Wes | C | Springfield Cardinals | 24 | 08/07/2047 | Keller | USA | Right | Right | 6' 5" | 230 lbs | - |
| Snow, Ed | 1B | Arkansas Travelers | 26 | 03/19/2045 | Kahuku | USA | Right | Right | 6' 0" | 200 lbs | - |
| Soliván, Arturo | RP | Free Agent | 32 | 01/29/2039 | La Romana | DOM | Left | Right | 6' 3" | 200 lbs | - |
| Soto, Cristo | CF | Corpus Christi Hooks | 29 | 06/15/2042 | Monongahela | USA | Left | Left | 6' 2" | 200 lbs | - |
| Stewart, Walt | RF | San Antonio Missions | 25 | 07/20/2046 | New York | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sugano, Eijiro | SP | Midland Rock Hounds | 22 | 06/08/2049 | Kitakyushu | JPN | Left | Left | 6' 2" | 175 lbs | - |
| Sullivan, Carlton | SP | Midland Rock Hounds | 24 | 04/06/2047 | Dallas | USA | Left | Left | 6' 5" | 200 lbs | - |
| Swift, Lawrence | RP | Northwest Arkansas Naturals | 27 | 05/14/2044 | Berwyn | USA | Right | Right | 6' 2" | 185 lbs | $750,000 |
| Sánchez, Carlos | SP | Midland Rock Hounds | 25 | 07/26/2046 | Lenoir City | USA | Right | Right | 6' 5" | 200 lbs | - |
| Sánchez, Edgar | RF | Northwest Arkansas Naturals | 25 | 05/25/2046 | Santo Domingo | DOM | Right | Right | 5' 10" | 185 lbs | - |
| Sánchez, Wilson | RP | Northwest Arkansas Naturals | 25 | 12/25/2045 | La Chorrera | PAN | Right | Right | 5' 11" | 185 lbs | - |
