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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sandoval, Jesús | SP | Lowell Spinners | 26 | 05/08/2045 | Pescadería | DOM | Right | Right | 6' 6" | 200 lbs | - |
| Sandoval, Sergio | SS | Lowell Spinners | 25 | 10/12/2045 | Panama | PAN | Right | Right | 6' 1" | 195 lbs | - |
| Santana, Cristián | CF | Aberdeen Ironbirds | 23 | 12/24/2047 | Bay City | USA | Left | Left | 6' 3" | 200 lbs | - |
| Santiago, Carlos | CL | Thunder Bay Chill | 24 | 12/20/2046 | Santa Lucía Cotzumalguapa | GUA | Right | Right | 6' 0" | 175 lbs | - |
| Santiago, Martín | RP | State College Spikes | 21 | 01/01/2050 | Medellín | COL | Left | Left | 5' 11" | 165 lbs | - |
| Savage, Ron | C | Brooklyn Cyclones | 21 | 11/16/2049 | Harrisburg | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sellers, Mal | RF | South Carolina Bombers | 21 | 02/19/2050 | Newtown Grant | USA | Right | Left | 6' 0" | 170 lbs | - |
| Seymour, Steve | SP | Williamsport Crosscutters | 22 | 02/23/2049 | Los Angeles | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sheppard, Paddy | 2B | Mahoning Valley Scrappers | 21 | 11/22/2049 | Sydney | AUS | Right | Right | 6' 4" | 200 lbs | - |
| Shimada, Michihiro | SP | Tri-City Valley Cats | 21 | 10/25/2049 | Katano | JPN | Right | Right | 6' 0" | 180 lbs | - |
| Shui, Shan-tang | SP | Lowell Spinners | 24 | 01/25/2047 | Kaohsiung | TPE | Right | Right | 6' 1" | 175 lbs | - |
| Silva, Arturo | C | Thunder Bay Chill | 21 | 10/12/2049 | West Orange | USA | Right | Right | 6' 4" | 205 lbs | - |
| Silva, Raúl | RP | Free Agent | 29 | 11/06/2041 | Grand Forks | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sims, Ben | SP | Lowell Spinners | 22 | 10/28/2048 | Kingston | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sloan, James | SP | Aberdeen Ironbirds | 23 | 08/14/2047 | New York | USA | Left | Left | 6' 1" | 200 lbs | - |
| Smith, Paul | RP | Thunder Bay Chill | 23 | 11/30/2047 | Cape Girardeau | USA | Left | Left | 6' 7" | 200 lbs | - |
| Smith, Tom | SP | Rocket City Trash Pandas | 22 | 09/29/2048 | San Clemente | USA | Right | Right | 6' 1" | 190 lbs | - |
| Smith, Wesley | CF | Williamsport Crosscutters | 21 | 08/02/2049 | Franconia | USA | Right | Right | 6' 0" | 185 lbs | - |
| Smyth, Vic | SP | Long Island Ducks | 20 | 01/11/2051 | Chaguanas | TRI | Right | Right | 6' 5" | 190 lbs | - |
| Solís, Javier | CL | Williamsport Crosscutters | 22 | 08/27/2048 | Santo Domingo | DOM | Left | Right | 6' 2" | 200 lbs | - |
| Sotelo, Pedro | CF | Aberdeen Ironbirds | 24 | 10/13/2046 | Cuauhtémoc | MEX | Left | Left | 6' 3" | 200 lbs | - |
| Soto, Luis | 1B | Tampa Bay Leaves | 22 | 05/28/2049 | Pinar del Rio | CUB | Right | Left | 6' 3" | 200 lbs | - |
| Souza, José | SP | Aberdeen Ironbirds | 23 | 08/07/2047 | Havana | CUB | Right | Right | 6' 3" | 195 lbs | - |
| Stewart, Michael | C | State College Spikes | 20 | 08/17/2050 | Las Vegas | USA | Left | Right | 6' 0" | 185 lbs | - |
| Sutherland, Cliff | SS | South Carolina Bombers | 21 | 10/23/2049 | Barrington Hills | USA | Right | Right | 6' 2" | 180 lbs | - |
| Swain, Greg | RP | Vermont Lake Monsters | 23 | 05/17/2048 | Myrtle Creek | USA | Left | Left | 6' 1" | 190 lbs | - |
| Sáenz, Roberto | RP | Free Agent | 25 | 06/19/2046 | Santo Domingo | DOM | Left | Left | 6' 2" | 195 lbs | - |
| Sánchez, Carlos | SP | Brooklyn Cyclones | 19 | 08/30/2051 | Cueto | CUB | Right | Right | 6' 2" | 190 lbs | - |
| Sánchez, José | SS | Brooklyn Cyclones | 24 | 06/06/2047 | Bayamón | PUR | Right | Right | 6' 0" | 185 lbs | - |
| Sánchez, Juan | SS | Bridgeport Blue Fish | 22 | 02/18/2049 | Humacao | PUR | Left | Right | 6' 1" | 175 lbs | - |
| Sánchez, Ricardo | SS | Brooklyn Cyclones | 21 | 12/21/2049 | Palma Soriano | CUB | Right | Right | 6' 1" | 175 lbs | - |
| Sánchez, Ricardo | SP | Mahoning Valley Scrappers | 20 | 07/24/2050 | Bayamón | PUR | Left | Left | 6' 2" | 165 lbs | - |
| Sánchez, Tony | SP | South Carolina Bombers | 21 | 03/13/2050 | Joliet | USA | Right | Right | 6' 2" | 175 lbs | - |
