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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Juan Blanca | 182 | 2021-2039 | |
| 2 | Johnny Cueto | 166 | 2015-2028 | |
| 3 | Ed Baxter# | 163 | 2020-2041 | |
| 4 | Tyler Kolek | 157 | 2017-2033 | |
| 5 | Julio Teheran | 156 | 2015-2031 | |
| 6 | Riley Pint | 155 | 2019-2034 | |
| 6 | Carlos A. Rodriguez | 155 | 2017-2035 | |
| 8 | César Barrón | 150 | 2022-2036 | |
| 8 | Jonathan Blanchard | 150 | 2024-2040 | |
| 8 | Greg Johnston | 150 | 2020-2037 | |
| 8 | Zane Washington | 150 | 2025-2038 | |
| 12 | Willie Anderson | 149 | 2020-2034 | |
| 13 | Jake Odorizzi | 144 | 2015-2029 | |
| 13 | Juan Ortíz | 144 | 2024-2037 | |
| 15 | Sean Baker | 143 | 2020-2035 | |
| 15 | Jim MacKinley | 143 | 2025-2040 | |
| 17 | Jose Fernandez | 142 | 2015-2028 | |
| 18 | Aaron Nola | 140 | 2017-2030 | |
| 18 | Alain Vidal | 140 | 2020-2035 | |
| 18 | Nolan Watson | 140 | 2019-2033 | |
| 21 | Bert Brooks | 139 | 2023-2037 | |
| 21 | Leonardo Flores | 139 | 2025-2039 | |
| 21 | Corey Kluber | 139 | 2015-2027 | |
| 24 | Juan Domínguez | 138 | 2021-2036 | |
| 25 | Raúl Valéncia# | 136 | 2025-2040 | |
| 26 | Pepe Esparza | 135 | 2022-2040 | |
| 26 | Manny Hernández | 135 | 2022-2037 | |
| 28 | Clarence Nelson | 134 | 2023-2037 | |
| 29 | Sonny Gray | 133 | 2015-2026 | |
| 29 | Sam Lucas | 133 | 2018-2033 | |
| 29 | Shelby Miller | 133 | 2016-2029 | |
| 32 | Jeremiah Badger | 132 | 2022-2038 | |
| 32 | Archie Bradley | 132 | 2015-2027 | |
| 32 | Esteban Rea | 132 | 2022-2037 | |
| 35 | Mike Flynn# | 131 | 2030-2042 | |
| 35 | Juan Méndez# | 131 | 2030-2042 | |
| 35 | Tyson Ross | 131 | 2015-2028 | |
| 35 | Justin Smith | 131 | 2017-2033 | |
| 39 | Dave Crawford | 130 | 2022-2037 | |
| 39 | Curt Pérez | 130 | 2023-2035 | |
| 41 | Phil Watkins# | 129 | 2028-2042 | |
| 42 | Manny Olivas | 127 | 2022-2038 | |
| 42 | Jorge Velázquez | 127 | 2025-2039 | |
| 44 | Mike Soroka | 126 | 2021-2034 | |
| 45 | Mike Armstrong# | 125 | 2029-2042 | |
| 45 | Marco Gonzales | 125 | 2015-2029 | |
| 45 | Dave Robinson# | 125 | 2029-2041 | |
| 48 | David García | 124 | 2020-2028 | |
| 48 | Raúl Martínez# | 124 | 2027-2042 | |
| 50 | Jeff Abbott# | 123 | 2030-2042 | |
| 50 | Robby Flowers | 123 | 2020-2037 | |
| 52 | Dallas Keuchel* | 122 | 2015-2030 | |
| 52 | Tony Martin# | 122 | 2029-2042 | |
| 52 | Noah Syndergaard | 122 | 2015-2028 | |
| 55 | Bob Andrzejewski | 121 | 2022-2036 | |
| 55 | Jake Green# | 121 | 2029-2042 | |
| 57 | Mathias Chevrier | 120 | 2027-2039 | |
| 57 | António Dueñas# | 120 | 2032-2042 | |
| 57 | Gilberto García# | 120 | 2029-2042 | |
| 60 | Kyle Crick | 119 | 2016-2028 | |
| 60 | Jacob deGrom | 119 | 2015-2026 | |
| 60 | Manny Fernández# | 119 | 2027-2042 | |
| 60 | Alfredo Morales# | 119 | 2030-2042 | |
| 64 | Randall Delgado | 118 | 2015-2026 | |
| 64 | Luis González# | 118 | 2029-2042 | |
| 64 | Pete Hale | 118 | 2024-2032 | |
| 64 | Manny Jiménez | 118 | 2025-2039 | |
| 64 | Doug Maze# | 118 | 2030-2042 | |
| 69 | Orlando Bernard# | 117 | 2020-2042 | |
| 69 | Lucas Giolito | 117 | 2016-2030 | |
| 69 | Cam James | 117 | 2024-2037 | |
| 69 | José López# | 117 | 2029-2042 | |
| 69 | Michael Matuella | 117 | 2017-2030 | |
| 69 | Kyle Zimmer | 117 | 2016-2029 | |
| 75 | Jeff Kennedy# | 116 | 2028-2041 | |
| 75 | Lance McCullers Jr. | 116 | 2016-2028 | |
| 75 | Carlos Rodon | 116 | 2015-2029 | |
| 78 | Thomas Szapucki | 115 | 2019-2033 | |
| 79 | Marco Hornby# | 114 | 2030-2042 | |
| 79 | José Perea | 114 | 2030-2040 | |
| 79 | Joe Walkup# | 114 | 2030-2042 | |
| 82 | A.J. Cole | 113 | 2015-2027 | |
| 82 | Jimmy Nelson | 113 | 2015-2027 | |
| 84 | Billy Hart# | 112 | 2032-2042 | |
| 84 | Sean Newcomb | 112 | 2016-2030 | |
| 84 | Cal Quantrill | 112 | 2017-2031 | |
| 87 | Sid Finch | 111 | 2017-2029 | |
| 87 | Andrew Heaney | 111 | 2016-2029 | |
| 89 | Ulrico Detillo | 110 | 2028-2041 | |
| 89 | Tim Ford* | 110 | 2020-2034 | |
| 89 | Luiz Gohara | 110 | 2018-2031 | |
| 89 | Anastasio Mendoza | 110 | 2028-2039 | |
| 93 | Chris Mills | 109 | 2021-2034 | |
| 93 | José Rosas | 109 | 2022-2036 | |
| 93 | Juan Vargas# | 109 | 2027-2042 | |
| 96 | Tony González | 108 | 2023-2035 | |
| 96 | Phil Riley | 108 | 2025-2038 | |
| 98 | Kenta Maeda | 107 | 2015-2026 | |
| 98 | Augusto Medina# | 107 | 2032-2042 | |
| 98 | Curt Muller | 107 | 2020-2030 |
