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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Iván | SS | Detroit (VSL) Tigers | 21 | 10/13/2008 | Valencia | VEN | Right | Right | 6' 2" | 180 lbs | - |
| Sánchez, Jim | RP | Detroit (VSL) Tigers | 26 | 10/21/2003 | Baldwin Park | USA | Right | Right | 6' 1" | 205 lbs | - |
| Sánchez, Jorge | SS | Detroit (VSL) Tigers | 20 | 11/08/2009 | Jackson | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sánchez, Manny | RP | Detroit (VSL) Tigers | 21 | 07/14/2008 | Gaspar Hernandez | DOM | Left | Right | 6' 2" | 190 lbs | - |
| Santistevan, António | SP | Tampa Bay (VSL) Rays | 23 | 01/25/2006 | Mérida | VEN | Right | Right | 6' 3" | 195 lbs | - |
| Savage, Bubba | 1B | Seattle (VSL) Mariners | 20 | 10/27/2009 | Hudson | USA | Right | Right | 6' 2" | 215 lbs | - |
| Schenkel, Larry | SP | Seattle (VSL) Mariners | 23 | 03/28/2006 | Melbourne | AUS | Right | Right | 5' 10" | 175 lbs | - |
| Schenyzer, Rogério | LF | Tampa Bay (VSL) Rays | 29 | 11/27/1999 | Maracaibo | VEN | Right | Right | 6' 2" | 220 lbs | - |
| Schmidt, Oscar | CF | Detroit (VSL) Tigers | 21 | 07/18/2008 | Houston | USA | Right | Right | 6' 0" | 180 lbs | - |
| Schmidt, Steffen | 2B | Detroit (VSL) Tigers | 21 | 05/15/2008 | Clifton Heights | USA | Right | Right | 6' 1" | 180 lbs | - |
| Schmitt, Eric | CF | Seattle (VSL) Mariners | 23 | 07/11/2006 | Thousand Oaks | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Serna, José | SP | Seattle (VSL) Mariners | 19 | 04/25/2010 | Broken Bow | USA | Right | Right | 5' 10" | 165 lbs | - |
| Shafer, Dave | SS | Detroit (VSL) Tigers | 21 | 03/15/2008 | Columbia | USA | Right | Right | 6' 2" | 180 lbs | - |
| Silva, Arturo | RP | Detroit (VSL) Tigers | 21 | 03/17/2008 | Maracaibo | VEN | Left | Left | 6' 4" | 195 lbs | - |
| Silva, Clint | LF | Seattle (VSL) Mariners | 18 | 01/08/2011 | Baton Rouge | USA | Right | Right | 6' 0" | 185 lbs | - |
| Silva, Ed | SP | Seattle (VSL) Mariners | 21 | 10/03/2008 | Bridgeview | USA | Left | Right | 6' 2" | 190 lbs | - |
| Silver, Dan | C | Arizona League Cubs 2 | 19 | 08/19/2010 | Jupiter | USA | Right | Right | 5' 10" | 185 lbs | - |
| Smith, Robby | 1B | Detroit (VSL) Tigers | 20 | 05/30/2009 | Saratoga Springs | USA | Right | Left | 6' 3" | 205 lbs | - |
| Smith, Willie | CF | Philadelphia (VSL) Phillies | 19 | 09/15/2010 | Peoria | USA | Left | Left | 6' 0" | 180 lbs | - |
| Soriano, Luis | CL | Arizona League Cubs 2 | 18 | 05/31/2011 | Ciudad Bolívar | VEN | Right | Right | 6' 2" | 180 lbs | - |
| Soto, José | RP | Arizona League Cubs 2 | 20 | 01/06/2009 | Moca | DOM | Right | Right | 6' 2" | 190 lbs | - |
| Stanley, Walt | RP | Detroit (VSL) Tigers | 20 | 07/03/2009 | Larchmont | USA | Right | Right | 6' 1" | 185 lbs | - |
| Stevense, Giel | RP | Detroit (VSL) Tigers | 22 | 06/18/2007 | Oranjestad | ANT | Right | Right | 6' 1" | 185 lbs | - |
| Strong, Chris | CL | Seattle (VSL) Mariners | 19 | 01/12/2010 | Fruit Cove | USA | Right | Right | 6' 0" | 180 lbs | - |
