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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Charles O'Brien | 2021-2024 | 6 | 8 | .429 | 4.12 | 77 | 10 | 0 | 0 | 6 | 172.2 | 185 | 79 | 22 | 52 | 131 |
| Darren O'Day | 2014-2017 | 4 | 6 | .400 | 4.73 | 62 | 0 | 0 | 0 | 29 | 59.0 | 66 | 31 | 7 | 22 | 36 |
| John O'Day | 2018-2018 | 10 | 4 | .714 | 2.30 | 17 | 17 | 0 | 0 | 0 | 101.2 | 77 | 26 | 2 | 26 | 89 |
| Eric O'Flaherty | 2016-2016 | 0 | 0 | .000 | 13.50 | 2 | 0 | 0 | 0 | 0 | 1.1 | 2 | 2 | 1 | 0 | 3 |
| Brett Oberholtzer | 2012-2021 | 41 | 24 | .631 | 4.35 | 120 | 83 | 0 | 0 | 0 | 523.0 | 487 | 253 | 76 | 152 | 493 |
| Jake Odorizzi | 2012-2023 | 29 | 12 | .707 | 3.20 | 81 | 49 | 5 | 1 | 2 | 368.0 | 312 | 131 | 37 | 119 | 354 |
| Alexi Ogando | 2018-2018 | 1 | 0 | 1.000 | 2.25 | 2 | 0 | 0 | 0 | 1 | 4.0 | 4 | 1 | 0 | 2 | 3 |
| Jefferson Olacio | 2019-2019 | 4 | 1 | .800 | 2.51 | 24 | 4 | 0 | 0 | 3 | 86.0 | 70 | 24 | 1 | 47 | 94 |
| Andrew Oliver | 2016-2019 | 14 | 13 | .519 | 3.31 | 42 | 36 | 4 | 2 | 0 | 228.1 | 202 | 84 | 19 | 71 | 163 |
| Lester Oliveros | 2012-2015 | 5 | 13 | .278 | 4.69 | 114 | 0 | 0 | 0 | 32 | 126.2 | 138 | 66 | 17 | 77 | 132 |
| Juan Oramas | 2023-2024 | 2 | 0 | 1.000 | 3.82 | 7 | 5 | 0 | 0 | 0 | 33.0 | 33 | 14 | 1 | 22 | 33 |
| Jose Ortega | 2012-2021 | 17 | 19 | .472 | 3.38 | 248 | 0 | 0 | 0 | 45 | 287.1 | 215 | 108 | 32 | 118 | 348 |
| Tyson Oswalt | 2020-2021 | 5 | 3 | .625 | 4.24 | 10 | 10 | 0 | 0 | 0 | 51.0 | 53 | 24 | 3 | 6 | 38 |
| Andy Otero | 2015-2022 | 2 | 2 | .500 | 5.45 | 7 | 7 | 0 | 0 | 0 | 38.0 | 42 | 23 | 3 | 16 | 33 |
| Tadaaki Otsuka | 2016-2023 | 13 | 17 | .433 | 3.67 | 128 | 18 | 0 | 0 | 19 | 267.0 | 287 | 109 | 28 | 66 | 221 |
| Teo Ottenhof | 2020-2020 | 0 | 1 | .000 | 6.00 | 8 | 0 | 0 | 0 | 4 | 9.0 | 14 | 6 | 2 | 2 | 4 |
| Juan Carlos Oviedo | 2015-2015 | 1 | 0 | 1.000 | 3.97 | 7 | 0 | 0 | 0 | 0 | 11.1 | 10 | 5 | 3 | 2 | 8 |
| Richard Owens | 2017-2022 | 4 | 5 | .444 | 3.35 | 79 | 0 | 0 | 0 | 12 | 110.0 | 119 | 41 | 11 | 23 | 85 |
| Jun'ichi Ozaki | 2016-2021 | 15 | 20 | .429 | 3.52 | 193 | 1 | 0 | 0 | 40 | 227.1 | 231 | 89 | 22 | 106 | 245 |
