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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sandoval, Orlando | CF | Binghamton Rumble Ponies | 24 | 12/12/1999 | Río Grande | PUR | Left | Left | 6' 0" | 190 lbs | - |
| Sandoval, Álex | SS | Reading Fightin Phils | 24 | 07/27/1999 | Egypt Lake-Leto | USA | Right | Right | 6' 0" | 180 lbs | - |
| Sanudo, Gonzalo | RP | Free Agent | 31 | 10/01/1992 | Tabasco | MEX | Left | Right | 6' 3" | 225 lbs | - |
| Schneider, Werner | 1B | Reading Fightin Phils | 24 | 08/21/1999 | Fort Myers | USA | Right | Right | 6' 4" | 205 lbs | - |
| Segura, Felipe | SS | Binghamton Rumble Ponies | 25 | 08/26/1998 | Irvine | USA | Right | Right | 6' 4" | 200 lbs | - |
| Self, Riley | CL | Erie SeaWolves | 25 | 07/30/1998 | Coldwater | USA | Right | Right | 6' 4" | 235 lbs | - |
| Sells, Bowman | SP | Bowie Baysox | 25 | 08/16/1998 | Lucas | USA | Left | Left | 6' 3" | 200 lbs | - |
| Serna, Lorenzo | C | Erie SeaWolves | 23 | 09/01/2000 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Serrano, Jorge | RP | Free Agent | 30 | 09/21/1993 | Barranquilla | COL | Right | Right | 6' 2" | 200 lbs | - |
| Sharp, Hayden | RP | Free Agent | 31 | 10/30/1992 | Unknown | USA | Right | Right | 6' 6" | 220 lbs | - |
| Shields, Vic | 1B | Akron RubberDucks | 24 | 08/02/1999 | San Diego | USA | Right | Right | 6' 1" | 190 lbs | - |
| Showalter, Zack | RP | Reading Fightin Phils | 23 | 05/07/2000 | Germantown | USA | Right | Right | 6' 3" | 200 lbs | - |
| Shuster, Jared | RP | Binghamton Rumble Ponies | 25 | 08/03/1998 | New Bedford | USA | Left | Left | 6' 3" | 205 lbs | - |
| Sikkema, T.J. | SP | Bowie Baysox | 25 | 07/25/1998 | De Witt | USA | Left | Left | 6' 0" | 220 lbs | - |
| Sims, Ryan | SP | Bowie Baysox | 26 | 08/02/1997 | Greenville | USA | Switch | Right | 6' 4" | 205 lbs | - |
| Slocum, Nathan | RP | Free Agent | 29 | 09/06/1994 | Christiansburg | USA | Left | Right | 6' 3" | 215 lbs | - |
| Smith, Dylan | SP | Binghamton Rumble Ponies | 23 | 05/28/2000 | Stafford | USA | Right | Right | 6' 2" | 185 lbs | - |
| Smith, Everth | 2B | Free Agent | 29 | 01/27/1995 | Redford | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Smith, Russell | RP | Binghamton Rumble Ponies | 25 | 09/10/1998 | Midlothian | USA | Left | Left | 6' 9" | 225 lbs | - |
| Solters, Nathan | RP | New Britain Rock Cats | 27 | 03/01/1997 | Richmond | USA | Right | Right | 6' 2" | 200 lbs | $750,000 |
| Solís, Raúl | LF | Free Agent | 26 | 08/02/1997 | San Juan | PUR | Left | Left | 6' 4" | 210 lbs | - |
| Soto, Roger | 2B | Altoona Curve | 26 | 08/25/1997 | The Bronx | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stanton, Richard | 2B | Reading Fightin Phils | 28 | 02/16/1996 | Addison | USA | Right | Right | 6' 0" | 205 lbs | - |
| Stewart, David | 1B | Free Agent | 25 | 06/12/1998 | Jersey City | USA | Switch | Right | 6' 1" | 200 lbs | - |
| Stroud, C.J. | SP | New Britain Rock Cats | 22 | 10/08/2001 | Rancho Cucamonga | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sulbaran, Miguel | RP | Free Agent | 30 | 03/19/1994 | Ciudad Ojeda | VEN | Left | Left | 5' 10" | 205 lbs | - |
| Sullivan, Corey | SP | New Hampshire Fisher Cats | 25 | 11/19/1998 | Spokane | USA | Right | Right | 6' 0" | 205 lbs | - |
| Sullivan, Jeff | RP | Altoona Curve | 25 | 11/22/1998 | Janesville | USA | Right | Right | 6' 8" | 225 lbs | - |
| Swiney, Nick | RP | Portland Sea Dogs | 25 | 02/12/1999 | Raleigh | USA | Right | Left | 6' 3" | 195 lbs | - |
| Sánchez, Esteban | 1B | New Britain Rock Cats | 31 | 11/05/1992 | Chihuahua | MEX | Left | Right | 6' 0" | 235 lbs | $750,000 |
| Sánchez, José | C | Harrisburg Senators | 22 | 08/27/2001 | Cotuí | DOM | Left | Right | 6' 3" | 195 lbs | - |
