| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonah Crane | SEA | MON | April 10, 2099 | 21-1 | 5 | 4 | 5 | 3 | 6 | 1 | 125 |
| 2 | Dirk Rehberg | VBJ | SF | June 22, 2099 | 13-9 | 4 | 4 | 6 | 3 | 4 | 1 | 122 |
| 3 | Jonathan Brown | ARI | NYM | April 28, 2099 | 12-2 | 5 | 5 | 4 | 3 | 5 | 0 | 118 |
| 4 | Juan Balderas | NSH | MON | April 9, 2099 | 10-8 | 4 | 4 | 6 | 3 | 3 | 1 | 115 |
| 5 | Juan López | KC | BAL | April 18, 2099 | 16-2 | 4 | 4 | 7 | 1 | 4 | 0 | 114 |
| 6 | Sammy Allen | CIN | SD | May 16, 2099 | 15-5 | 6 | 5 | 7 | 1 | 3 | 0 | 111 |
| 7 | Chris Dorsey | PIT | ARI | Aug. 28, 2099 | 13-9 | 6 | 6 | 5 | 1 | 3 | 0 | 109 |
| 8 | César Trejo | ARI | ORL | May 13, 2099 | 13-2 | 5 | 3 | 8 | 3 | 3 | 0 | 108 |
| 9 | António Bautista | OAK | SD | May 30, 2099 | 16-6 | 3 | 3 | 6 | 2 | 3 | 2 | 107 |
| 10 | Chris Hart | ATL | CIN | April 17, 2099 | 9-4 | 5 | 4 | 6 | 3 | 3 | 0 | 106 |
| 11 | Orlando Valentín | NYY | KC | April 13, 2099 | 7-5 | 4 | 4 | 7 | 2 | 2 | 0 | 105 |
| 12 | Edgardo Durán | SD | LAD | June 16, 2099 | 15-8 | 6 | 5 | 5 | 1 | 4 | 0 | 104 |
| 13 | Sammy Allen | ARI | CIN | Aug. 26, 2099 | 11-1 | 4 | 4 | 4 | 2 | 4 | 1 | 103 |
| 14 | Manny Colón | ORL | MIL | June 26, 2099 | 6-10 | 4 | 4 | 5 | 3 | 3 | 0 | 103 |
| 15 | Pat Bryant | STL | WAS | Aug. 21, 2099 | 14-7 | 4 | 3 | 6 | 3 | 3 | 1 | 103 |
| 16 | Mike Summers | MON | PHI | Aug. 9, 2099 | 8-5 | 6 | 6 | 5 | 1 | 2 | 0 | 102 |
| 17 | Jim Clark | DET | BOS | May 28, 2099 | 11-12 | 5 | 5 | 6 | 1 | 2 | 0 | 101 |
| 18 | José Mejía | NSH | LAA | July 17, 2099 | 13-14 | 5 | 5 | 2 | 1 | 5 | 1 | 99 |
| 19 | Eric Allen | MIL | CHC | April 22, 2099 | 10-8 | 5 | 3 | 6 | 3 | 3 | 1 | 99 |
| 20 | Andy Allen | ORL | DET | Aug. 7, 2099 | 11-12 | 5 | 4 | 5 | 3 | 3 | 0 | 99 |
| 21 | Juan Guardado | TEX | STL | July 1, 2099 | 19-6 | 6 | 5 | 5 | 0 | 4 | 0 | 99 |
| 22 | Steve Perry | ORL | CIN | April 29, 2099 | 6-1 | 5 | 5 | 4 | 2 | 3 | 0 | 99 |
| 23 | Ian Johnston | BOS | CWS | May 24, 2099 | 9-2 | 4 | 3 | 5 | 2 | 4 | 1 | 98 |
| 24 | Wouter van Hal | SF | LAD | July 27, 2099 | 11-0 | 4 | 4 | 5 | 2 | 3 | 0 | 98 |
| 25 | Sam Cooper | CLE | CHC | July 2, 2099 | 15-4 | 4 | 4 | 5 | 1 | 3 | 1 | 98 |
| 26 | Dan Edmonds | BAL | MON | May 3, 2099 | 20-2 | 6 | 4 | 5 | 1 | 4 | 1 | 97 |
| 27 | Donnie Santiago | NSH | KC | Aug. 16, 2099 | 12-8 | 6 | 4 | 6 | 2 | 3 | 0 | 97 |
| 28 | Jesús Vega | MIN | SD | Aug. 9, 2099 | 18-2 | 6 | 4 | 6 | 2 | 3 | 0 | 97 |
| 29 | Alex Yates | WAS | NYY | Aug. 7, 2099 | 16-6 | 6 | 5 | 5 | 1 | 3 | 0 | 97 |
| 30 | Dan Davis | BAL | CWS | Sept. 5, 2099 | 12-9 | 5 | 4 | 6 | 1 | 3 | 0 | 96 |