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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| O'Connor, Don | SP | Fredericksburg Nationals | 20 | 08/14/2021 | Kansas City | USA | Right | Right | 5' 10" | 170 lbs | - |
| O'Farranan, Wilbert | SP | Salem Red Sox | 23 | 10/29/2018 | Concord | USA | Right | Right | 5' 11" | 185 lbs | - |
| O'Malquiney, Jeff | RP | Kannapolis Cannon Ballers | 31 | 07/01/2010 | Morgan Hill | USA | Right | Right | 6' 0" | 200 lbs | - |
| O'Mullan, Bob | C | Columbia Fireflies | 36 | 03/06/2006 | Duncanville | USA | Switch | Right | 6' 0" | 200 lbs | - |
| O'Neil, Pat | RP | Columbia Fireflies | 24 | 08/24/2017 | Bedford | USA | Right | Right | 6' 2" | 200 lbs | - |
| O'Rorke, Ed | RP | Carolina Mudcats | 26 | 08/07/2015 | Elgin | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Oliveira, António | SP | Carolina Mudcats | 26 | 06/05/2016 | Santiago | DOM | Switch | Right | 6' 2" | 195 lbs | - |
| Orosco, Luis | SP | Salem Red Sox | 20 | 08/12/2021 | Guarenas | VEN | Left | Right | 6' 2" | 180 lbs | - |
| Orozco, Juan | RP | Carolina Mudcats | 25 | 07/20/2016 | Baní | DOM | Right | Right | 6' 0" | 190 lbs | - |
| Ortega, Cristo | SS | Delmarva Shorebirds | 23 | 09/06/2018 | Higüey | DOM | Right | Right | 6' 1" | 190 lbs | - |
| Ortíz, Alfredo | LF | Carolina Mudcats | 25 | 12/24/2016 | Comendador | DOM | Right | Right | 6' 0" | 190 lbs | - |
| Ortíz, Edgardo | 1B | Columbia Fireflies | 39 | 10/09/2002 | Santiago | DOM | Right | Right | 6' 4" | 195 lbs | - |
| Ortíz, Jorge | RP | Charleston RiverDogs | 28 | 06/11/2014 | Changuinola | PAN | Right | Right | 6' 1" | 195 lbs | $750,000 |
| Ortíz, Kevin | SS | Columbia Fireflies | 34 | 02/24/2008 | Bethlehem | USA | Right | Right | 6' 0" | 195 lbs | - |
| Ortíz, Orlando | RP | Lynchburg Hillcats | 22 | 12/31/2019 | Santo Domingo | DOM | Right | Left | 6' 2" | 185 lbs | - |
| Ortíz, Ron | 2B | Fayetteville Woodpeckers | 23 | 12/11/2018 | Ottawa | USA | Right | Right | 5' 9" | 175 lbs | - |
| Owens, Tony | CF | Columbia Fireflies | 22 | 12/17/2019 | Seattle | USA | Right | Right | 6' 1" | 190 lbs | - |
