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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salas, Ernesto | SS | Myrtle Beach Pelicans | 19 | 07/01/2022 | Esperanza | DOM | Right | Right | 6' 0" | 170 lbs | - |
| Salas, Jesús | 1B | Kannapolis Cannon Ballers | 27 | 11/20/2014 | Santo Domingo | DOM | Left | Left | 6' 2" | 200 lbs | - |
| Salas, José | CF | Free Agent | 32 | 05/21/2010 | Cartagena | COL | Left | Left | 6' 1" | 200 lbs | - |
| Salazar, Jorge | SP | Salem Red Sox | 21 | 01/21/2021 | Santo Domingo | DOM | Left | Left | 6' 2" | 190 lbs | - |
| Salinas, Arturo | RP | Free Agent | 32 | 10/26/2009 | Atenas | CRC | Right | Right | 6' 0" | 200 lbs | - |
| Salinas, Pancho | RP | Salem Red Sox | 24 | 11/07/2017 | La Vega | DOM | Left | Left | 6' 1" | 185 lbs | - |
| Sanchez, Stéphane | SP | Fayetteville Woodpeckers | 22 | 08/16/2019 | Barrie | CAN | Switch | Right | 5' 9" | 165 lbs | - |
| Sandoval, Freddy | CF | Myrtle Beach Pelicans | 22 | 02/08/2020 | Greenfield | USA | Switch | Right | 6' 4" | 200 lbs | - |
| Santana, Orlando | RP | Augusta GreenJackets | 32 | 01/01/2010 | Guaynabo | PUR | Left | Left | 6' 2" | 200 lbs | - |
| Santegoeds, Itze | RP | Lynchburg Hillcats | 22 | 06/15/2020 | Rotterdam | NED | Right | Right | 6' 2" | 190 lbs | - |
| Schmidt, Tommy | 1B | Fayetteville Woodpeckers | 25 | 07/27/2016 | Simi Valley | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sellers, Chris | RP | Columbia Fireflies | 25 | 03/06/2017 | North Charleston | USA | Switch | Right | 6' 4" | 200 lbs | - |
| Shaw, Ron | C | Columbia Fireflies | 21 | 12/16/2020 | Falmouth | USA | Right | Right | 6' 5" | 200 lbs | - |
| Sherlag Jr., Anthony | SP | Delmarva Shorebirds | 22 | 11/20/2019 | Charlotte | USA | Left | Right | 6' 6" | 205 lbs | - |
| Sherman, Chris | 2B | Down East Wood Ducks | 26 | 07/05/2015 | Dent | USA | Right | Right | 6' 0" | 190 lbs | - |
| Simmons, Dan | SP | Salem Red Sox | 23 | 11/07/2018 | Orange | USA | Left | Left | 6' 3" | 205 lbs | - |
| Simpson, Mike | 1B | Kannapolis Cannon Ballers | 32 | 11/21/2009 | Hartford | USA | Left | Left | 6' 4" | 200 lbs | - |
| Small, Andy | CL | Delmarva Shorebirds | 24 | 05/16/2018 | Kahalu'u-Keauhou | USA | Left | Right | 6' 2" | 200 lbs | - |
| Small, Steve | 3B | Salem Red Sox | 22 | 02/04/2020 | Ennis | USA | Left | Right | 6' 2" | 200 lbs | - |
| Smith, Don | LF | Kannapolis Cannon Ballers | 29 | 07/22/2012 | Northampton | USA | Right | Right | 6' 0" | 200 lbs | - |
| Solís, Juan | SS | Delmarva Shorebirds | 24 | 10/17/2017 | Bajos de Haina | DOM | Right | Right | 6' 0" | 195 lbs | - |
| Soriano, António | RP | Columbia Fireflies | 21 | 04/16/2021 | Santo Domingo | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Spence, Tad | RP | Carolina Mudcats | 26 | 07/25/2015 | Santa Fe | USA | Right | Right | 6' 4" | 195 lbs | - |
| Spivey, Derek | SP | Columbia Fireflies | 21 | 11/03/2020 | Los Angeles | USA | Left | Right | 6' 3" | 180 lbs | - |
| Stallings, Steve | RP | Carolina Mudcats | 26 | 04/27/2016 | Four Corners | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stanley, Phil | 1B | Fredericksburg Nationals | 24 | 09/22/2017 | South Plainfield | USA | Left | Left | 6' 2" | 205 lbs | - |
| Stewart, Alan | RP | Free Agent | 29 | 04/14/2013 | Glendale | USA | Right | Right | 6' 5" | 200 lbs | - |
| Stone, Ken | 3B | Delmarva Shorebirds | 25 | 06/03/2017 | Roswell | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stuart, Warner | SP | Salem Red Sox | 22 | 11/27/2019 | Orillia | CAN | Right | Right | 6' 4" | 200 lbs | - |
| Sullivan, José | CF | Augusta GreenJackets | 27 | 04/17/2015 | Chicago | USA | Left | Left | 6' 0" | 195 lbs | - |
| Sullivan, Tyrone | CF | Charleston RiverDogs | 24 | 11/03/2017 | Bellingham | USA | Right | Right | 6' 1" | 190 lbs | - |
| Summers, Chris | RP | Free Agent | 31 | 04/24/2011 | Van Buren | USA | Left | Right | 6' 2" | 205 lbs | - |
| Suzuki, Sadatake | RP | Charleston RiverDogs | 32 | 04/26/2010 | Tokyo | JPN | Switch | Right | 6' 4" | 200 lbs | - |
| Sáenz, Jorge | SP | Myrtle Beach Pelicans | 24 | 01/25/2018 | Bajos de Haina | DOM | Left | Right | 6' 1" | 175 lbs | - |
| Sánchez, António | SS | Columbia Fireflies | 25 | 10/14/2016 | San Cristóbal | DOM | Right | Right | 6' 3" | 195 lbs | - |
| Sánchez, Raúl | LF | Kannapolis Cannon Ballers | 35 | 04/08/2007 | Santo Domingo | DOM | Left | Left | 6' 3" | 200 lbs | - |
| Sánchez, Wilson | C | Carolina Mudcats | 21 | 01/30/2021 | San Pedro de Macorís | DOM | Right | Right | 6' 6" | 195 lbs | - |
