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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Riley O'Brien | 2019-2023 | 16 | 24 | .400 | 4.27 | 99 | 52 | 0 | 0 | 3 | 367.0 | 343 | 174 | 27 | 185 | 396 |
| Darren O'Day | 2021-2021 | 3 | 3 | .500 | 3.96 | 29 | 0 | 0 | 0 | 5 | 36.1 | 39 | 16 | 4 | 9 | 41 |
| Jack O'Loughlin | 2021-2021 | 0 | 1 | .000 | 14.73 | 1 | 1 | 0 | 0 | 0 | 3.2 | 6 | 6 | 1 | 3 | 2 |
| Tyler O'Neill | 2019-2021 | 0 | 0 | .000 | 3.00 | 2 | 0 | 0 | 0 | 0 | 3.0 | 2 | 1 | 1 | 1 | 2 |
| Trevor Oaks | 2019-2021 | 6 | 6 | .500 | 3.56 | 57 | 1 | 0 | 0 | 1 | 141.2 | 128 | 56 | 7 | 54 | 123 |
| Bailey Ober | 2021-2023 | 10 | 7 | .588 | 3.48 | 37 | 19 | 0 | 0 | 3 | 142.1 | 139 | 55 | 24 | 27 | 156 |
| Scott Oberg | 2021-2023 | 1 | 2 | .333 | 1.36 | 25 | 0 | 0 | 0 | 6 | 33.0 | 22 | 5 | 1 | 9 | 25 |
| Jake Odorizzi | 2019-2023 | 9 | 9 | .500 | 5.01 | 28 | 25 | 2 | 1 | 0 | 147.1 | 160 | 82 | 17 | 55 | 119 |
| Shohei Ohtani | 2019-2019 | 1 | 0 | 1.000 | 1.50 | 1 | 1 | 0 | 0 | 0 | 6.0 | 4 | 1 | 1 | 2 | 2 |
| Steven Okert | 2022-2022 | 0 | 0 | .000 | 14.73 | 3 | 0 | 0 | 0 | 0 | 3.2 | 7 | 6 | 2 | 1 | 4 |
| Jon Olczak | 2020-2022 | 0 | 6 | .000 | 4.00 | 61 | 0 | 0 | 0 | 8 | 92.1 | 101 | 41 | 11 | 38 | 92 |
| Helcris Olivarez | 2023-2023 | 0 | 0 | .000 | 5.40 | 1 | 1 | 0 | 0 | 0 | 5.0 | 8 | 3 | 0 | 5 | 2 |
| Luis Ortiz | 2019-2022 | 27 | 23 | .540 | 3.47 | 112 | 55 | 0 | 0 | 2 | 417.0 | 354 | 161 | 41 | 140 | 436 |
| Robinson Ortiz | 2022-2022 | 0 | 1 | .000 | 3.00 | 1 | 0 | 0 | 0 | 0 | 3.0 | 3 | 1 | 0 | 2 | 0 |
| Eric Orze | 2023-2023 | 1 | 0 | 1.000 | 4.91 | 19 | 2 | 0 | 0 | 0 | 29.1 | 35 | 16 | 3 | 12 | 26 |
| Josh Osich | 2020-2023 | 10 | 6 | .625 | 2.73 | 93 | 0 | 0 | 0 | 3 | 142.0 | 106 | 43 | 16 | 37 | 180 |
| Roberto Osuna | 2019-2020 | 0 | 0 | .000 | 1.93 | 11 | 0 | 0 | 0 | 1 | 9.1 | 8 | 2 | 0 | 4 | 7 |
| Corey Oswalt | 2021-2023 | 6 | 10 | .375 | 4.27 | 26 | 20 | 0 | 0 | 0 | 128.2 | 125 | 61 | 18 | 19 | 142 |
| Andy Otero | 2023-2023 | 2 | 2 | .500 | 4.89 | 12 | 3 | 0 | 0 | 1 | 35.0 | 40 | 19 | 3 | 11 | 32 |
| Adam Ottavino | 2020-2022 | 5 | 2 | .714 | 3.74 | 49 | 0 | 0 | 0 | 2 | 74.2 | 69 | 31 | 3 | 36 | 95 |
| Glenn Otto | 2019-2023 | 14 | 5 | .737 | 3.32 | 40 | 14 | 0 | 0 | 9 | 105.2 | 82 | 39 | 11 | 56 | 108 |
| Connor Overton | 2023-2023 | 9 | 7 | .562 | 3.49 | 18 | 18 | 0 | 0 | 0 | 126.1 | 132 | 49 | 4 | 36 | 92 |
| Luis Oviedo | 2020-2023 | 11 | 6 | .647 | 3.98 | 39 | 20 | 0 | 0 | 9 | 133.1 | 107 | 59 | 11 | 44 | 186 |
