| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Carlos Correa | COL | CHC | April 17, 2022 | 18-1 | 4 | 3 | 9 | 3 | 4 | 1 | 131 |
| 2 | Shohei Ohtani | ARI | LAD | May 16, 2022 | 6-4 | 5 | 4 | 6 | 3 | 3 | 0 | 106 |
| 3 | Dave Tatum | BAL | KC | May 7, 2022 | 13-4 | 4 | 3 | 6 | 2 | 4 | 1 | 105 |
| 4 | David Davies | KC | MIN | April 19, 2022 | 10-0 | 3 | 3 | 6 | 2 | 3 | 1 | 102 |
| 5 | Jed McKinley | SEA | HOU | May 3, 2022 | 9-10 | 5 | 3 | 8 | 2 | 2 | 1 | 101 |
| 6 | Roberto Freitas | SD | CHC | May 11, 2022 | 12-6 | 6 | 4 | 8 | 1 | 2 | 0 | 99 |
| 7 | Giancarlo Stanton | TOR | CIN | May 22, 2022 | 10-4 | 4 | 4 | 5 | 2 | 3 | 0 | 98 |
| 8 | Trevor Story | OAK | CLE | April 30, 2022 | 6-5 | 5 | 4 | 4 | 3 | 3 | 1 | 97 |
| 9 | Seiya Suzuki | BOS | NYY | April 7, 2022 | 18-9 | 6 | 3 | 7 | 3 | 3 | 0 | 97 |
| 10 | Fernando Tatis Jr. | HOU | ARI | April 13, 2022 | 9-2 | 4 | 3 | 5 | 3 | 3 | 1 | 96 |
| 11 | Keston Hiura | DET | OAK | April 5, 2022 | 11-1 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 12 | Joey Moran | SF | CLE | April 15, 2022 | 13-6 | 3 | 3 | 5 | 2 | 2 | 2 | 93 |
| 13 | Bryce Harper | ARI | STL | May 1, 2022 | 9-8 | 3 | 3 | 5 | 2 | 2 | 2 | 93 |
| 14 | Mike Solaz | NYM | PHI | May 7, 2022 | 12-13 | 3 | 2 | 5 | 2 | 3 | 3 | 93 |
| 15 | Elvis Andrus | NYM | ARI | April 22, 2022 | 11-7 | 5 | 3 | 7 | 1 | 3 | 0 | 91 |
| 16 | Juan Soto | LAD | SD | April 23, 2022 | 15-4 | 4 | 3 | 6 | 1 | 2 | 2 | 91 |
| 17 | Jordon Adell | MIN | OAK | May 16, 2022 | 8-2 | 4 | 4 | 4 | 2 | 2 | 1 | 89 |
| 18 | Conner Capel | NYM | WAS | May 10, 2022 | 11-1 | 3 | 3 | 4 | 1 | 3 | 2 | 88 |
| 19 | Alonso MartÃnez | COL | KC | May 14, 2022 | 13-5 | 5 | 5 | 4 | 1 | 2 | 0 | 87 |
| 20 | George Springer | BOS | TEX | May 13, 2022 | 15-4 | 4 | 2 | 6 | 2 | 3 | 1 | 86 |
| 21 | Steve Winter | COL | CHC | April 17, 2022 | 18-1 | 5 | 4 | 4 | 0 | 4 | 0 | 84 |
| 22 | Jose Abreu | LAD | SD | April 23, 2022 | 15-4 | 4 | 2 | 5 | 2 | 3 | 2 | 84 |
| 23 | Gary Copeland | MIN | BOS | April 18, 2022 | 12-5 | 4 | 4 | 3 | 1 | 2 | 2 | 82 |
| 24 | Jordan Akins | TEX | HOU | April 27, 2022 | 7-2 | 3 | 3 | 3 | 2 | 3 | 1 | 81 |
| 25 | George Springer | BOS | NYY | April 10, 2022 | 9-5 | 3 | 2 | 4 | 2 | 3 | 2 | 81 |
| 26 | Nomar Mazara | LAA | TEX | April 14, 2022 | 12-4 | 3 | 2 | 5 | 2 | 2 | 2 | 81 |
| 27 | Matt Jenkins | SEA | KC | April 24, 2022 | 5-6 | 5 | 5 | 2 | 1 | 3 | 0 | 80 |
| 28 | Jerry MacDonal | LAD | PHI | May 20, 2022 | 10-2 | 5 | 4 | 3 | 2 | 3 | 0 | 80 |
| 29 | Braulio Pardo | TOR | HOU | April 22, 2022 | 6-3 | 4 | 3 | 5 | 2 | 2 | 0 | 79 |
| 30 | Russell Nicholas | WAS | ARI | April 19, 2022 | 9-7 | 4 | 4 | 3 | 1 | 3 | 0 | 79 |