| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Nick Delmonico | CIN | CLE | April 18, 2021 | 9-8 | 5 | 4 | 6 | 3 | 4 | 0 | 113 |
| 2 | Ryobe Kamida | PHI | NYM | May 2, 2021 | 11-10 | 4 | 4 | 5 | 2 | 3 | 2 | 108 |
| 3 | Gary Sanchez | NYY | CLE | April 24, 2021 | 14-5 | 4 | 3 | 6 | 2 | 3 | 2 | 103 |
| 4 | Juan Espinoza | STL | PIT | April 30, 2021 | 11-2 | 5 | 4 | 6 | 2 | 3 | 0 | 101 |
| 5 | Ryobe Kamida | PHI | NYM | May 1, 2021 | 8-3 | 2 | 2 | 5 | 2 | 4 | 2 | 99 |
| 6 | Anthony Rizzo | OAK | LAD | April 7, 2021 | 15-3 | 5 | 4 | 6 | 1 | 3 | 0 | 96 |
| 7 | Jorge Ayala | CLE | KC | April 5, 2021 | 10-4 | 4 | 3 | 5 | 3 | 3 | 1 | 96 |
| 8 | Juan Francisco | OAK | HOU | April 1, 2021 | 9-2 | 5 | 5 | 5 | 1 | 2 | 0 | 94 |
| 9 | Ed Palmer | WAS | NYY | May 9, 2021 | 13-5 | 3 | 2 | 5 | 2 | 3 | 3 | 93 |
| 10 | Cade Cahill | CLE | MIN | April 27, 2021 | 20-3 | 3 | 2 | 4 | 2 | 4 | 3 | 93 |
| 11 | Jorge Ayala | CLE | NYY | April 22, 2021 | 17-6 | 3 | 2 | 5 | 2 | 3 | 3 | 93 |
| 12 | Joc Pederson | SEA | HOU | April 16, 2021 | 12-8 | 4 | 4 | 4 | 2 | 3 | 0 | 91 |
| 13 | César López | MIA | NYM | April 10, 2021 | 9-7 | 4 | 3 | 4 | 3 | 3 | 1 | 89 |
| 14 | Xue-liang Wong | NYM | MIA | April 10, 2021 | 7-9 | 5 | 3 | 7 | 2 | 2 | 0 | 89 |
| 15 | Taylor Sparks | ATL | PHI | April 11, 2021 | 8-2 | 4 | 4 | 3 | 2 | 3 | 1 | 89 |
| 16 | Don Winston | TOR | LAA | April 10, 2021 | 20-3 | 5 | 3 | 6 | 2 | 2 | 1 | 87 |
| 17 | Chris Betts | CLE | NYY | April 22, 2021 | 17-6 | 3 | 2 | 4 | 2 | 3 | 3 | 86 |
| 18 | Arinori Arai | NYY | BAL | April 6, 2021 | 14-0 | 4 | 3 | 5 | 2 | 2 | 1 | 84 |
| 19 | Carlos Romero | MIN | OAK | April 20, 2021 | 12-3 | 4 | 3 | 4 | 2 | 3 | 1 | 84 |
| 20 | Ramón Zaragoza | CHW | TEX | April 24, 2021 | 7-1 | 3 | 2 | 6 | 2 | 2 | 1 | 83 |
| 21 | Alec Bohm | PIT | MIL | April 18, 2021 | 10-7 | 5 | 3 | 6 | 2 | 2 | 0 | 82 |
| 22 | Ed Palmer | WAS | STL | April 13, 2021 | 10-7 | 4 | 3 | 5 | 1 | 3 | 0 | 81 |
| 23 | Miguel Velazquez | NYY | BAL | April 26, 2021 | 5-3 | 6 | 5 | 3 | 2 | 2 | 0 | 81 |
| 24 | Nick Williams | CLE | MIN | April 27, 2021 | 20-3 | 4 | 2 | 5 | 1 | 3 | 2 | 79 |
| 25 | Gary Copeland | MIN | DET | May 7, 2021 | 13-9 | 4 | 3 | 4 | 1 | 3 | 1 | 79 |
| 26 | Keston Hiura | DET | KC | April 23, 2021 | 9-4 | 4 | 4 | 3 | 0 | 3 | 1 | 79 |
| 27 | Yasiel Puig | STL | MIA | April 5, 2021 | 8-1 | 2 | 2 | 4 | 2 | 2 | 2 | 78 |
| 28 | Nolan Arenado | MIN | MIL | April 1, 2021 | 12-8 | 3 | 2 | 5 | 1 | 3 | 1 | 78 |
| 29 | Miguel Sano | NYY | CLE | April 24, 2021 | 14-5 | 5 | 5 | 2 | 1 | 2 | 1 | 78 |
| 30 | Maikel Franco | TOR | LAA | April 10, 2021 | 20-3 | 5 | 4 | 2 | 2 | 3 | 1 | 78 |