| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Richard Fowler | HOU | OAK | July 6, 2021 | 17-5 | 5 | 4 | 6 | 2 | 5 | 1 | 120 |
| 2 | Nick Delmonico | CIN | CLE | April 18, 2021 | 9-8 | 5 | 4 | 6 | 3 | 4 | 0 | 113 |
| 3 | William Gray | TBR | BAL | July 20, 2021 | 9-8 | 6 | 6 | 3 | 1 | 5 | 0 | 109 |
| 4 | Ryobe Kamida | PHI | NYM | May 2, 2021 | 11-10 | 4 | 4 | 5 | 2 | 3 | 2 | 108 |
| 5 | Mark Baker | SEA | TEX | July 2, 2021 | 11-5 | 3 | 3 | 4 | 2 | 5 | 2 | 107 |
| 6 | Gary Sanchez | NYY | CLE | April 24, 2021 | 14-5 | 4 | 3 | 6 | 2 | 3 | 2 | 103 |
| 7 | Brett Lawrie | CHW | STL | May 26, 2021 | 10-2 | 3 | 3 | 6 | 2 | 3 | 1 | 102 |
| 8 | Juan Espinoza | STL | PIT | April 30, 2021 | 11-2 | 5 | 4 | 6 | 2 | 3 | 0 | 101 |
| 9 | Francisco Lindor | SEA | CLE | June 11, 2021 | 13-4 | 5 | 3 | 6 | 2 | 4 | 1 | 101 |
| 10 | Bo Bichette | ATL | BOS | May 25, 2021 | 11-4 | 5 | 4 | 5 | 2 | 4 | 0 | 101 |
| 11 | Jed McKinley | COL | SEA | July 20, 2021 | 10-4 | 3 | 3 | 6 | 2 | 2 | 2 | 100 |
| 12 | Miguel Velazquez | NYY | TBR | June 3, 2021 | 11-3 | 3 | 3 | 5 | 2 | 3 | 2 | 100 |
| 13 | Ryobe Kamida | PHI | NYM | May 1, 2021 | 8-3 | 2 | 2 | 5 | 2 | 4 | 2 | 99 |
| 14 | Matt Den Dekker | NYM | MIA | May 23, 2021 | 8-6 | 4 | 4 | 3 | 2 | 4 | 1 | 96 |
| 15 | Keon Barnum | CHW | NYY | May 23, 2021 | 15-4 | 5 | 3 | 7 | 2 | 3 | 0 | 96 |
| 16 | Jorge Ayala | CLE | KC | April 5, 2021 | 10-4 | 4 | 3 | 5 | 3 | 3 | 1 | 96 |
| 17 | Anthony Rizzo | OAK | LAD | April 7, 2021 | 15-3 | 5 | 4 | 6 | 1 | 3 | 0 | 96 |
| 18 | Miguel Sano | NYY | BOS | June 27, 2021 | 15-9 | 4 | 3 | 4 | 2 | 4 | 2 | 96 |
| 19 | Juan Francisco | OAK | HOU | April 1, 2021 | 9-2 | 5 | 5 | 5 | 1 | 2 | 0 | 94 |
| 20 | Ed Palmer | WAS | NYY | May 9, 2021 | 13-5 | 3 | 2 | 5 | 2 | 3 | 3 | 93 |
| 21 | Cade Cahill | CLE | MIN | April 27, 2021 | 20-3 | 3 | 2 | 4 | 2 | 4 | 3 | 93 |
| 22 | Jorge Ayala | CLE | NYY | April 22, 2021 | 17-6 | 3 | 2 | 5 | 2 | 3 | 3 | 93 |
| 23 | Gary Copeland | MIN | CHW | May 19, 2021 | 11-5 | 4 | 3 | 6 | 1 | 3 | 1 | 93 |
| 24 | Joc Pederson | SEA | HOU | April 16, 2021 | 12-8 | 4 | 4 | 4 | 2 | 3 | 0 | 91 |
| 25 | Edgardo Arredondo | HOU | BOS | June 10, 2021 | 11-5 | 4 | 4 | 5 | 1 | 2 | 1 | 91 |
| 26 | Juan Sánchez | MIL | CIN | July 11, 2021 | 12-2 | 3 | 2 | 7 | 2 | 2 | 1 | 90 |
| 27 | César López | MIA | NYM | April 10, 2021 | 9-7 | 4 | 3 | 4 | 3 | 3 | 1 | 89 |
| 28 | Xue-liang Wong | NYM | MIA | April 10, 2021 | 7-9 | 5 | 3 | 7 | 2 | 2 | 0 | 89 |
| 29 | Jerry MacDonal | LAD | COL | July 16, 2021 | 9-8 | 5 | 4 | 6 | 1 | 2 | 0 | 89 |
| 30 | Taylor Sparks | ATL | PHI | April 11, 2021 | 8-2 | 4 | 4 | 3 | 2 | 3 | 1 | 89 |