| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Freddy Peralta | SF | CHC | April 9, 2022 | 5-0 | 8.2 | 0 | 1 | 0 | 1 | 14 | 102 |
| 2 | Gerrit Cole | ATL | BAL | July 29, 2022 | 7-0 | 9.0 | 0 | 1 | 0 | 1 | 11 | 101 |
| 3 | Luis Garcia | SF | CHW | June 10, 2022 | 4-0 | 9.0 | 0 | 1 | 0 | 2 | 13 | 101 |
| 4 | Marcus Stroman | PHI | TOR | April 23, 2022 | 6-0 | 9.0 | 0 | 0 | 0 | 1 | 7 | 99 |
| 5 | Eric Lauer | SEA | LAA | April 8, 2022 | 8-0 | 9.0 | 0 | 1 | 0 | 3 | 12 | 98 |
| 6 | Brandon Woodruff | SF | SD | June 14, 2022 | 4-0 | 8.0 | 0 | 1 | 0 | 1 | 13 | 97 |
| 7 | Noah Syndergaard | NYY | TOR | April 2, 2022 | 5-0 | 9.0 | 0 | 3 | 0 | 1 | 11 | 97 |
| 8 | Walker Buehler | LAA | CHC | July 8, 2022 | 9-0 | 9.0 | 0 | 4 | 0 | 0 | 10 | 96 |
| 9 | Brandon Woodruff | SF | TEX | April 5, 2022 | 2-0 | 8.0 | 0 | 2 | 0 | 0 | 10 | 94 |
| 10 | MacKenzie Gore | LAA | PHI | June 2, 2022 | 1-0 | 8.2 | 0 | 3 | 0 | 2 | 12 | 94 |
| 11 | MacKenzie Gore | LAA | LAD | July 29, 2022 | 1-0 | 9.0 | 0 | 5 | 0 | 0 | 10 | 94 |
| 12 | Max Fried | LAD | TEX | July 22, 2022 | 0-1 | 9.0 | 0 | 4 | 0 | 1 | 10 | 94 |
| 13 | Pablo Lopez | BOS | NYY | June 18, 2022 | 10-8 | 7.2 | 0 | 2 | 0 | 0 | 12 | 94 |
| 14 | Devin Smeltzer | NYM | BAL | June 17, 2022 | 7-0 | 8.2 | 0 | 1 | 0 | 2 | 7 | 93 |
| 15 | Clayton Kershaw | SF | BAL | May 9, 2022 | 6-2 | 8.0 | 1 | 1 | 0 | 1 | 12 | 93 |
| 16 | Max Fried | LAD | CHC | May 3, 2022 | 6-5 | 8.0 | 0 | 2 | 0 | 0 | 9 | 93 |
| 17 | Frankie Montas | STL | LAA | July 20, 2022 | 7-0 | 7.1 | 0 | 1 | 0 | 0 | 11 | 93 |
| 18 | Frankie Montas | STL | LAA | June 8, 2022 | 3-0 | 8.1 | 0 | 3 | 0 | 1 | 10 | 92 |
| 19 | Framber Valdez | LAD | MIA | July 25, 2022 | 7-0 | 9.0 | 0 | 3 | 0 | 2 | 7 | 91 |
| 20 | Brandon Woodruff | SF | MIA | May 8, 2022 | 8-0 | 8.0 | 0 | 3 | 0 | 0 | 9 | 91 |
| 21 | Zach Plesac | CHC | LAA | July 10, 2022 | 16-0 | 9.0 | 0 | 1 | 0 | 1 | 1 | 91 |
| 22 | Freddy Peralta | SF | SEA | April 1, 2022 | 13-0 | 9.0 | 0 | 4 | 0 | 4 | 13 | 91 |
| 23 | Gregory Santos | SEA | SD | July 6, 2022 | 1-0 | 8.0 | 0 | 2 | 0 | 1 | 9 | 91 |
| 24 | Dylan Cease | BOS | MIA | May 25, 2022 | 4-0 | 7.0 | 0 | 2 | 0 | 0 | 12 | 90 |
| 25 | Tanner Houck | TEX | SD | May 7, 2022 | 8-0 | 9.0 | 0 | 3 | 0 | 3 | 7 | 89 |
| 26 | Stephen Strasburg | PHI | NYM | May 27, 2022 | 2-0 | 9.0 | 0 | 4 | 0 | 2 | 7 | 89 |
| 27 | Zack Wheeler | LAD | LAA | May 6, 2022 | 5-0 | 8.0 | 0 | 3 | 0 | 1 | 9 | 89 |
| 28 | Noah Syndergaard | NYY | WAS | July 20, 2022 | 6-5 | 7.1 | 0 | 2 | 0 | 0 | 9 | 89 |
| 29 | Tyler Mahle | BOS | HOU | July 19, 2022 | 3-0 | 8.1 | 0 | 4 | 0 | 2 | 11 | 89 |
| 30 | Luis Severino | NYY | MIA | April 7, 2022 | 2-0 | 9.0 | 0 | 4 | 0 | 1 | 5 | 89 |