| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Freddy Peralta | SF | CHC | April 9, 2022 | 5-0 | 8.2 | 0 | 1 | 0 | 1 | 14 | 102 |
| 2 | Corbin Burnes | TEX | CHW | Aug. 3, 2022 | 3-0 | 8.1 | 0 | 1 | 0 | 0 | 14 | 102 |
| 3 | Gerrit Cole | ATL | BAL | July 29, 2022 | 7-0 | 9.0 | 0 | 1 | 0 | 1 | 11 | 101 |
| 4 | Luis Garcia | SF | CHW | June 10, 2022 | 4-0 | 9.0 | 0 | 1 | 0 | 2 | 13 | 101 |
| 5 | Marcus Stroman | PHI | TOR | April 23, 2022 | 6-0 | 9.0 | 0 | 0 | 0 | 1 | 7 | 99 |
| 6 | Eric Lauer | SEA | LAA | April 8, 2022 | 8-0 | 9.0 | 0 | 1 | 0 | 3 | 12 | 98 |
| 7 | Brandon Woodruff | SF | SD | June 14, 2022 | 4-0 | 8.0 | 0 | 1 | 0 | 1 | 13 | 97 |
| 8 | Gerrit Cole | ATL | BAL | Oct. 7, 2022 | 4-0 | 8.1 | 0 | 1 | 0 | 1 | 11 | 97 |
| 9 | Noah Syndergaard | NYY | TOR | April 2, 2022 | 5-0 | 9.0 | 0 | 3 | 0 | 1 | 11 | 97 |
| 10 | Walker Buehler | LAA | CHC | July 8, 2022 | 9-0 | 9.0 | 0 | 4 | 0 | 0 | 10 | 96 |
| 11 | Zack Wheeler | LAD | BAL | Aug. 16, 2022 | 5-0 | 9.0 | 0 | 2 | 0 | 1 | 8 | 96 |
| 12 | Pablo Lopez | BOS | WAS | Sept. 13, 2022 | 4-0 | 9.0 | 0 | 5 | 0 | 0 | 12 | 96 |
| 13 | Brandon Woodruff | SF | TEX | April 5, 2022 | 2-0 | 8.0 | 0 | 2 | 0 | 0 | 10 | 94 |
| 14 | MacKenzie Gore | LAA | PHI | June 2, 2022 | 1-0 | 8.2 | 0 | 3 | 0 | 2 | 12 | 94 |
| 15 | MacKenzie Gore | LAA | LAD | July 29, 2022 | 1-0 | 9.0 | 0 | 5 | 0 | 0 | 10 | 94 |
| 16 | Noah Syndergaard | NYY | BAL | Sept. 15, 2022 | 7-0 | 8.2 | 0 | 2 | 0 | 0 | 6 | 94 |
| 17 | Max Fried | LAD | TEX | July 22, 2022 | 0-1 | 9.0 | 0 | 4 | 0 | 1 | 10 | 94 |
| 18 | Pablo Lopez | BOS | NYY | June 18, 2022 | 10-8 | 7.2 | 0 | 2 | 0 | 0 | 12 | 94 |
| 19 | Jaime Barria | MIA | SEA | Oct. 8, 2022 | 7-0 | 9.0 | 0 | 2 | 0 | 1 | 6 | 94 |
| 20 | Devin Smeltzer | NYM | BAL | June 17, 2022 | 7-0 | 8.2 | 0 | 1 | 0 | 2 | 7 | 93 |
| 21 | Brendan McKay | MIA | BAL | Sept. 17, 2022 | 6-0 | 9.0 | 0 | 3 | 0 | 1 | 7 | 93 |
| 22 | Clayton Kershaw | SF | BAL | May 9, 2022 | 6-2 | 8.0 | 1 | 1 | 0 | 1 | 12 | 93 |
| 23 | Trevor Rogers | PHI | MIA | Sept. 2, 2022 | 9-0 | 8.1 | 0 | 1 | 0 | 2 | 9 | 93 |
| 24 | Nathan Eovaldi | STL | SEA | Sept. 12, 2022 | 7-0 | 9.0 | 0 | 3 | 0 | 1 | 7 | 93 |
| 25 | Max Fried | LAD | CHC | May 3, 2022 | 6-5 | 8.0 | 0 | 2 | 0 | 0 | 9 | 93 |
| 26 | Frankie Montas | STL | LAA | July 20, 2022 | 7-0 | 7.1 | 0 | 1 | 0 | 0 | 11 | 93 |
| 27 | Pablo Lopez | BOS | BAL | Aug. 23, 2022 | 3-0 | 9.0 | 0 | 0 | 0 | 4 | 7 | 93 |
| 28 | Logan Gilbert | NYM | PHI | Aug. 12, 2022 | 4-0 | 9.0 | 0 | 4 | 0 | 1 | 9 | 93 |
| 29 | Jack Flaherty | STL | CHC | Sept. 9, 2022 | 2-0 | 8.0 | 0 | 3 | 0 | 1 | 12 | 92 |
| 30 | Devin Smeltzer | NYM | ATL | Aug. 3, 2022 | 6-1 | 9.0 | 1 | 2 | 0 | 0 | 5 | 92 |